Lefortovo Station is located in the Eastern Administrative District of Moscow, between Izmaylovsky Park and the Sokolnaya Gora area. The station's name is related to its location in the territory of the former third Lefortovo zemstvo district.

In the late 19th century, the Lefortovo area was bounded by two railway lines: the Moscow-Kursk and Moscow-Kazan. The area actively developed industrially: the blacksmith and locksmith workshop of A.K. Dangaueur, founded in 1869, transformed by 1873 into the Kotelny Mechanical and Copper Apparatus Factory of Dangaueur and Kaiser. After the revolution, the factory was nationalized and renamed "Compressor," starting to produce refrigeration equipment. However, the historical name associated with the founder was preserved in the name of the workers' settlement at the updated factory, built in 1931 under the guidance of M.I. Motylev. Today, the residential ensemble "Dangauerovka" is a cultural heritage site that retains features of Soviet architectural avant-garde.

In 1881, a sorting station of the Moscow-Ryazan Railway and wagon workshops (now the Moscow Locomotive Repair Plant) were built in Lefortovo. This led to the construction at the border of the Lefortovo area, near Vladimirsky Highway (now Enthusiasts' Highway), of a station of the Moscow Circular Railway and connecting branch No. 10 for exchanging cars with the Moscow-Kazan and Nizhny Novgorod railways.

Today, the Lefortovo station complex includes a passenger building, a residential house, and a track barracks. The passenger building, constructed according to a standard design, is replicated at the Rostokino and Ugresha stations. In its central part, there was a waiting room with three tall windows, while in the side wing, the station master's office and telegraph were located. The batteries for powering the telegraph were conveniently placed in the basement, which was considered safer for telegraph operators.

The residential house was designed to accommodate apartments and rooms for all station personnel. The facade retains joinery window fillings from the early 20th century. The barracks, located in the southern part of the complex, is one of eleven that have survived on the Moscow Railway. Originally located at: Enthusiasts' Highway, 42A, it was relocated due to the construction of the Fourth Transport Ring to the passenger building of the station, which has preserved its architectural design.