In 1868, the former estate of Major General M.V. Polyakova became the territory of the Komissarov Technical School, which was under the patronage of the Ladies' Guardianship for the Poor. Architect K.V. Grinevsky reconstructed the main building of the school from a residential house with an annex. The two-story yellow building (structure 6) follows the line of Blagoveshchensky Lane.

The school was founded in 1865, and in 1866 it was named after the cap maker O.I. Komissarov, who saved Emperor Alexander II from an assassination attempt by D.V. Karakozov on April 4, 1866.

Initially, the school was located in a small house on Trëkhprudny Lane, but thanks to donations from entrepreneur Pyotr Ionovich Gubonin and educator Christian Christianovich Meien, it was possible to acquire a large estate, which later expanded with neighboring plots.

The school was created to train skilled mechanics, particularly for locomotive factories. It had educational mechanical workshops and a carriage factory located on both sides of Bolshaya Sadovaya Street.

Admission to the school was difficult, with a competition of 6-7 applicants per place. Students lived in a boarding house at the school.

The curriculum included the Law of God, Russian language, history, German language, several courses in mathematics, physics, mechanics, and drawing.

By the beginning of the 20th century, the Komissarov School occupied the entire territory from Tverskaya Street to Yermolaevsky Lane, bordered by Bolshaya Sadovaya Street and Blagoveshchensky Lane. The building on Blagoveshchensky Lane housed a dining room, an assembly hall, and utility rooms.

In 1871, at the initiative of P. Gubonin, a house church named after Alexander Nevsky, the patron of Emperor Alexander II, was established in the end part of the building. The architect of the church was Grinevsky, but the project was refined by sculptor P.S. Campioni.

During the Soviet years, the church was abolished, but a few years ago, during the restoration of the building, it was converted back into a church space.

The main building of the school is connected by a passage to the central educational building (structure 3), built in 1891-92 according to the design of architect M.K. Geppener. The red-brick building with light brick ornamentation is characteristic of this Moscow architect.

The educational building housed scientific, drawing, and drafting classes. The vestibule and cloakroom were located in a separate one-story annex connected to the three-story administrative building, which housed the director's apartment, office, and physics room.

On the territory of the school, there were wooden and stone houses with apartments for staff, a laundry, a hospital for students, as well as a sports ground, running and cycling tracks, an ice rink, a bowling alley, and a tennis court.

The renovation of the school's classroom building in the 1880-1900s involved architect N.A. Ipatiev.

In the summer of 1904, the central building was raised by a fourth floor, where laboratories were located: physical, electrical engineering, electrical measurement, and mechanical.

After 1917, the Komissarov Technical School was transformed into the First Moscow Mechanical and Electrical Technical School, and then into the M.V. Lomonosov Institute under the leadership of G.M. Krizhanovsky.

In the 1930s, the buildings housed institutes: the Agricultural Engineering Institute named after M.I. Kalinin, the Automobile Tractor Institute, the Automobile Mechanics Institute named after I.V. Stalin, and the Machine Engineering Institute named after I.L. Lepse.

In the 1980s, the complex of educational buildings on Blagoveshchensky Lane belonged to the Ministry of Defense of the USSR, housing the Military-Political Academy named after V.I. Lenin.

In 1986, a project was developed to build a new academy building on the site of the former main building of the KTU while preserving the front facades and including the northeastern "dome part" (church) in the planned volume. The project was partially implemented: in 1989, a dining building for the academy was constructed at the intersection of Blagoveshchensky and Yermolaevsky Lanes, while the old KTU building remained unharmed.

In 1996, the building of the former main KTU building with the church was privatized and sold at auction. In 2002, the owner received permission for its reconstruction with the addition of two floors and the creation of a two-level underground parking lot, committing to restore the Alexander Nevsky Church to its original form for transfer to the Russian Orthodox Church.

In 2009, the building was recognized as a cultural heritage site and placed under state protection, after which the project excluded the construction of additional floors and underground garages.

By this time, the building was in an emergency state: the roof was missing, the ceilings had collapsed, and the wooden structures had rotted. Artificial marble and parquet in the interiors were partially preserved. According to the restoration project, three facades were restored, the main one and two end ones (one of which was located 80 centimeters from the neighboring building built in the Soviet era). The rotted internal ceilings were replaced. Since the existing foundations were laid at a shallow depth (60-80 cm from the ground level), they were injected and strengthened, but it was decided not to subject them to excessive load. For this purpose, a new independent frame of the building with a roof was created, which did not rest on the old outer walls.

The interiors of the church and the ceremonial hall on the second floor adjacent to the church were restored. Before extracting the collapsed ceilings, all decorative elements were dismantled, which were restored directly on site. They were fully recreated without loss. In the church space, the drum and dome were restored. The wooden structures of the church's tent, which had an unusual shape, were preserved to relieve their load, and the vault was reinforced with a metal frame.

Currently, the building houses the business center "Residence 'House on Mayakovka'", where various companies and offices are located.

In 2012, a complex of emergency and restoration works was completed. The object became a laureate of the Moscow Government competition for the best project in the field of preservation and popularization of cultural heritage sites "Moscow Restoration."