Researchers studying the history of the Urals, especially the Kama region from the 16th to the 20th centuries, often encounter the need to explore the history of the famous Russian family of entrepreneurs and patrons, the Stroganovs. On April 9, 1529, the Stroganovs received a charter for salt production in Solvychegodsk. In the second half of the 16th century, they expanded their holdings in Great Perm. The first charter for the Great Perm lands was issued by Ivan the Terrible to Grigory Stroganov, marking the beginning of the Stroganovs' possessions in this region. Census records of Great Perm from the 16th to 17th centuries mention a wooden church in honor of St. Nicholas the Wonderworker in the Kudymkor parish of the Solikamsk district. It is believed that the church was built at the initiative and with the support of Grigory Stroganov. Kri voshchikov I.Ya. notes that between 1579 and 1623, a wooden church was built in Kudymkor. In the 17th century, the church possessed significant wealth, including icons and church books.

The antiquity of the parish is confirmed by the presence of a bell in the church with a Latin inscription "Gloria Soli Deo" and the date "1646", as well as a prayer book by Peter Mogila from 1647. Malakhov M.V. also mentions this.

In 1749, after the division among the Stroganov brothers, Kudymkor and its surroundings were inherited by Alexander Sergeyevich Stroganov. He owned Kudymkar from 1756 to 1811 and built a new stone St. Nicholas Church on the site of the old wooden church.

There are discrepancies regarding the dates of the church's construction. Konin G.K. points to 1792-1795, while Kri voshchikov I.Ya. believes the building was completed in 1796. The church consisted of altar, summer, and winter parts, with the bell tower rising above the other structures. The architecture of the church combined baroque elements and geometric ornaments. The church had three altars: a cold church in honor of the Forty Martyrs, a warm church in honor of St. Nicholas, and a church in honor of St. Paraskeva.

The architect of the St. Nicholas Church remains unknown. There is a version that the project might have been developed by Andrey Nikiforovich Voronikhin, but there is no documentary evidence to support this. The issue requires further study.

In the 19th and early 20th centuries, the church was actively engaged in educational and charitable activities. By the early 1870s, the church owned significant land parcels. In 1875, it was decided that meadow land would be used by the clergy, while field land would be rented by peasants.

In 1891, the church's rector became Yakov Vasilyevich Shestakov, who actively engaged in educational activities. In 1892, under his leadership, a school was built at the Melyukhinskaya Church. For his efforts, Shestakov received gratitude from the Perm Spiritual Consistory.

In 1917, a difficult period began for the church. The Bolsheviks proclaimed the separation of church and state but effectively controlled its activities. The church lost its property, and in 1930, its activities were completely banned. The church building was repurposed as a museum.

During the perestroika years, believers began to seek the return of church buildings. In 1990, the building was transferred to the community of the Russian Orthodox Church in Kudymkar. Since then, the story of the church's revival began. Currently, the church operates according to the Statute adopted in 1999 and approved by the Archbishop of Perm and Solikamsk, Athanasius.