In 1834, the Moscow evangelical-reformed community acquired a plot of land in Malaya Trehsvyatitel'skaya Lane (modern address, ownership No. 3), where there was a stone residential house built in the late 18th century. Ten years later, architect V.A. Balashov reconstructed this building to adapt it for worship services.

The Calvinists moved here to Ivanovskaya Hill from the German settlement. In the German settlement, since 1694, there stood a brick reformed church at the corner of German (now Baumanskaya) Street and Dutch (now Denisovsky) Lane, next to which the famous general Franz Lefort, a comrade of Peter I, was buried. The church burned down in the fire of 1812, and for some time services were held in a partially restored building until the relocation took place.

Over time, the number of parishioners significantly increased, and in 1865 the building in Trehsvyatitel'skaya was completely reconstructed according to the design of architect G.I. von Nissen. The facade was designed in the eclectic style popular at the time. Above the central entrance, a two-part "Italian" window appeared, and the building was crowned with a pediment. In 1898, an organ created by the famous German master Ernst Reverb was installed in the main hall. It is now recognized as a monument of history and culture.

The church was also famous for its organist G. Müller. Among the parishioners were notable figures such as photographer M. Sherer and his partner P. Nabgol'ts, as well as banker F. Junker.

In 1913 and 1915, a three-story building for the reformed school was constructed behind the church, facing Bolshoy Trehsvyatitel'sky Lane, designed by architect A.E. Erikhson, a member of the community.

After the revolution, many parishioners emigrated, and the building in Trehsvyatitel'skaya was handed over to evangelical Christians, who united with Baptists in 1944. For a long time, this place remained the only one open for Protestant worship in Moscow. For example, after the closure and demolition of the church on Voznesenskaya Street in 1928, the Lutheran community of St. Michael found refuge here.

In 1937, part of the premises was taken from the evangelical Christians and converted into a dormitory. The residents were only relocated in 1965 thanks to the acquisition of three cooperative apartments funded by the All-Union Council of Evangelical Christians-Baptists. A secondary school was opened in the building of the former reformed school, which still operates today.

In 1940, the Moscow community of Seventh-day Adventists joined the evangelical Christians. Six years later, due to the growing number of parishioners, the prayer hall was reconstructed: galleries for 500 people appeared along the walls, and the balcony in front of the organ was extended for the choir.

In the summer of 1972, the church was visited by U.S. President Richard Nixon during his visit to Moscow.

Today, it houses the Moscow Central Church of Evangelical Christians-Baptists. On certain days, Seventh-day Adventists also hold their services here. Concerts of organ music are regularly held in the building.