The large five-domed church was built by architects A.F. Meissner and A.A. Nikiforov in 1894-1897 as the main temple of the Clinical Town of Moscow University at Devichye Pole. Professor A.M. Makeev, who headed the Obstetrics Clinic, became the benefactor of the church.

The consecration of the church marked the completion of the construction of the clinical town. It became a home for all clinics at Devichye Pole, and its parishioners included doctors, staff, patients, and students. The church often baptized infants born in the Obstetrics Clinic.

The church is located at the intersection of Pogodinskaya and Yelanskogo streets, opening onto the Alley of Life, formed by the buildings of the Clinical Town.

A.M. Makeev, a deeply religious man, envisioned building a hospital church in honor of the archangel Michael, the patron of his brother. In addition to a one-time donation for construction, he financed its arrangement and maintenance. During the construction, another donation was received from E.V. Solovyeva, an employee of the obstetrics clinic.

The church was owned by the university and was considered one of the best in Moscow.

In 1911, chapels of Alexander Nevsky and the martyr Catherine were added in honor of the main benefactor and his sister.

During World War I, the clinical town became a hospital, and the priests of the church cared for many wounded soldiers. This continued until the revolution of 1917.

In 1918, the church became an ordinary parish, and its property was declared "people's property." In 1922, the property was confiscated, including more than a pood of precious items and the shroud.

In 1931, the church was closed to organize a workers' club for the "Kauchuk" factory.

At different times, the building housed a "cultural enlightenment reading room," a gym, a pharmacy, a warehouse, and an institute museum. The heads and bell tower were demolished, new windows were made, the interior decoration was destroyed, and partitions were arranged.

In 1976, at the initiative of the 1st Moscow Medical Institute named after I.M. Sechenov, the building was planned for demolition. It was saved by the famous restorer P.D. Baranovsky, but by that time, a third of the church had already been destroyed. The half-ruined church stood until the 1990s when funds were found for its restoration.

At the initiative of the rector of the Medical Academy M.A. Paltsev, both buildings of the former clinical churches were transferred to the Russian Orthodox Church.

The great consecration of the church took place on September 19, 2002, on the day of the memory of the miracle of the archistrateg Michael at Chone. The consecration was conducted by Patriarch Alexy II of Moscow and All Russia.

The church icon of the archangel Michael, adorned with crosses, was brought from the Church of Nicholas the Wonderworker in Khamovniki. The church also houses rare icons: the image of the Mother of God "Helper in Childbirth," "Healer," and the icon of the great martyr Catherine, the patroness of children and helper in childbirth. Here are relics of the great martyrs Panteleimon and Theodore Tyron.