The church, dedicated to the holy and righteous prince Alexander Nevsky, is located on the southern side of the monastery. According to historical data, the abbot, hieromonk Gennady, received a blessing to build a hospital with a church in honor of Prince Alexander Nevsky in 1810. The construction was completed in 1816, and the consecration of the church took place in 1817.

The renowned historian and local historian S.B. Bakhmustov notes that the Alexander Nevsky church was part of the complex and occupied a subordinate position, complementing the Spaso-Transfiguration Cathedral, which was located at the center of the ensemble. The southern side of the complex began with a tower or pavilion, adjacent to the now-lost cell building. The line continued with the elongated Alexander Nevsky church, whose cube and dome completed this part of the perimeter and harmonized with the corner towers. The architects intended for the church not to stand out among the other buildings: the monastery had only two tall dominants, the cathedral and the bell tower, while the other structures were meant to create a spiritual landscape.

During the Soviet era, the church was almost completely rebuilt and leveled with the cell buildings: the head, triangular pediments, and dome were demolished. The building was converted into a club, some window openings were bricked up, and others were expanded. Frescoes, the iconostasis, and icons were destroyed. The partitions that separated the nave into hospital cells and separated the medical department from the church were demolished. Only traces of rustication on the facades and a semicircular apse remained.

The faithful achieved the return of the shrine in 1992-1993, but reconstruction only began in 2004. As a result of extensive restoration work, the Alexander Nevsky church regained its completed appearance. The church's superstructure with a golden dome, roof, and partially finished facade were restored. The snow-white walls, needing painting, new floor, high dome, royal gates, icons, and church utensils returned the interior decoration of the church to its former splendor.

On April 4, 2010, on the day of the Resurrection of Christ, services resumed in the church after repairs, and in 2011, work began on the construction of the lost sacristy and novice buildings.