The Cherkasskaya asylum for women was founded by Princess N.A. Cherkasskaya around 1858. At the same time, the first wooden church of the Holy Trinity appeared on the site along the Petersburg highway.

In the early 19th century, the land belonged to Osip Bove, where his summer house was located. In 1853, the land was purchased by Princess Nadezhda Alexeyevna Cherkasskaya, the widow of the hero of the 1812 war, Nikolai Cherkassky.

The princess decided to create an asylum for elderly women without means on her property and received a blessing from Metropolitan of Moscow Philaret (Drozdov). In a large wooden house, 15 women lived. A church of the Holy Trinity was built at the asylum, with a project developed by architect N.I. Finistov. The asylum was managed by the Imperial Philanthropic Society.

After the princess's death, she was buried with her husband on the church grounds, and merchant Nikolai Spiridonov took over the affairs of the asylum. Under him, a craft school for girls was opened, and the number of residents significantly increased.

After the merchant's death, his widow, Vera Bogdanovna Spiridonova, arranged a new chapel in honor of St. Nicholas the Wonderworker at the church in memory of her husband in 1888. The architect was N.A. Voskresensky. In 1893, a stone porch was added to the church, replacing the wooden one. The project was developed by P.P. Zykov-son.

Construction on the asylum grounds continued. In 1898, two-story brick buildings in the neo-Russian style were erected instead of the wooden structures, designed by I.P. Mashkov. They were connected to the church.

The place was renamed Spiridonovskoye shelter for incurable patients.

After the October Revolution, the church was closed. In 1921, the rector Ioann Milovidov was repressed. In 1922, the buildings of the asylum housed the House of Mother and Child named after Lenin-Krupskaya, and from 1928, the outpatient clinic named after P.F. Lesgaft. In the 1950s, a children's clinic opened in the asylum buildings, which still operates today. In the 2000s, the church was transferred to the Russian Orthodox Church.