In October 1990, a meeting was held at the Kuzhener District Committee of the Communist Party of the Soviet Union dedicated to the opening of the district museum. Vladislav Vasilyevich Popov was appointed as the museum director, who began collecting materials during his time as an instructor at the district committee. He visited villages, gathering exhibits, while schools and the district party committee assisted by providing their materials and library.

On November 7, 1990, the first exhibition of the museum was opened in the building of the former refectory of the St. Nicholas Women's Monastery. According to the order of the Ministry of Culture dated January 21, 1991, the museum became a branch of the republican museum named after Yevseev. In January 1997, by order of the Ministry of Culture and Nationalities Affairs, the museum came under the management of the Kuzhener Department of Culture, and its collection numbered 1,259 items.

On October 21, 2007, by the decree of the head of the Kuzhener District Administration, the municipal cultural institution "Kuzhener District Museum and Exhibition Center" was established, and the museum received legal entity status. Over the years, the museum has been enriched with new exhibits, conducts tours, workshops, museum lessons, exhibitions, and celebrations.

The museum features several exhibitions: an ethnographic exhibition "Peasant Life of the Late 19th and Early 20th Century" with a peasant hut and a collection of household items and national costumes; an exhibition "Invaluable Scatter of Eras" with tools and fragments of ceramics from the Stone and Iron Ages; a model of the Kuzhener Monastery complex; an exhibition "I Call This Land My Homeland," telling about the history and modern life of the village of Kuzhener and the district; a Hall of Glory dedicated to significant historical events such as the Great Patriotic War, the participation of Soviet troops in Afghanistan and the Chechen War, as well as the tragedy at the Chernobyl Nuclear Power Plant and the fates of the district's residents; and the working office of V.M. Regeh-Gorokhov, showcasing his personal belongings and awards.

Every month, new exhibitions are opened in one of the museum's halls. The foundation of the museum consists of its collections, which currently include 2,000 items in the main collection and 4,325 in the scientific auxiliary collection. In 2019, the museum underwent cosmetic repairs and updated its exhibitions.