On the site of the modern Church of the Transfiguration of the Lord, built between 1886 and 1888, there previously stood the Spaso-Transfiguration Monastery, located on the banks of the Shchodnya River (formerly known as Vshodnya). The monastery, which existed from the 14th century until the mid-18th century, gave its name to the nearby village of Spasskoye. Another neighboring village, Tushino, got its name from the nickname of the landowner Rodion Nesterovich Kvashnya, known as "Tusha."

During the Time of Troubles, the monastery was destroyed, and later fell into decline, being abolished in 1764. One of its churches, the Church of the Transfiguration, became a parish church for the residents of the villages of Spasskoye and Tushino. In the second half of the 18th century, there arose a need to expand or rebuild the church due to the increasing number of parishioners and the dilapidated state of the building. Additionally, its location on the edge of a high riverbank, prone to landslides, caused concern among the locals.

In the 1870s, it was decided to dismantle the old church and build a new stone one at the opposite end of the main street of Spasskoye, away from the river. The project for the new church was developed by architect Vladislav Osipovich Gruzdin. After the demolition of the old refectory and bell tower, the surviving bricks were used to construct a fence around the new church.

The architecture of the new Church of the Transfiguration reflected the revival of national Russian traditions in church architecture. The high single-domed square was topped with kokoshniks and an onion dome on a blind drum. The massive volume was emphasized by a three-part apse, above which rose the icon cases with icons. The main volume of the church was balanced by a tall three-tiered bell tower. The red-brick walls were left unplastered, highlighting the whitewashed details against them. The central altar was adorned with a five-tiered iconostasis.

The church was consecrated by Metropolitan of Moscow and Kolomna Ioannikiy on the Feast of the Transfiguration of the Lord on August 6, 1886.

After the 1917 revolution, church lands were nationalized, and the bell tower and dome of the church were demolished. The church building was initially converted into a club for workers, and later it was used as a storage facility for building materials.

In 1990, Patriarch of Moscow and All Russia Alexy II consecrated the church, and services resumed.

With the return of the church to the Russian Orthodox Church, restoration began. In the 1990s, the bell tower, the main dome, and two small gilded domes, as well as the icon cases above the apses, were restored. The tympanums of the kokoshniks and the icon cases were decorated with mosaic panels. Based on preserved fragments, a lace fence on a brick base was recreated, and the Holy Gates were restored.