Protopopovsky Lane extends east from Prospekt Mira, roughly halfway between the Garden Ring and the Third Transport Ring (Kresty Square, Riga Station Square). It connects the initial sections of the main and duplicate routes of Yaroslavl Highway, namely Prospekt Mira and Pereyaslavskaya Street. This area of Moscow was developed quite late. In 1706, the Apothecary Garden was moved here, to the desolate area east of Rostov Highway, which had previously been located near the Kremlin on Vozdvizhenka (the territory of the Talizyn estate, now the A.V. Shchusev Museum of Architecture). In 1806, the garden was transferred to Moscow University, and it became the basis for the Botanical Garden, which has been preserved south of Protopopovsky Lane, originally called the Apothecary Garden.

In the late 19th and early 20th centuries, the northern part of the lane, already known as Protopopovsky (likely named after the owner of one of the plots), was occupied by the Brotherhood Society. With its funds, a charitable complex was built here, which included a House of Cheap Apartments and the Marieninskoe Almshouse. The architect was I.P. Mashkov, who served as the architect for the Brotherhood Society.

The complex of cheap apartment houses on Protopopovsky Lane is interesting because it was built in several stages over a short period. It consists of several low-rise buildings. The first projects were developed by I.P. Mashkov in 1890, and construction was completed in 1898. The main requirement was to reduce construction costs, so the buildings are modestly decorated, but even in the first stage, classical pediments were incorporated into the facades.

In 1910, the buildings were renovated, adding decorative reliefs in the style of Empire and Neo-Empire. These works were carried out in anticipation of the 100th anniversary of the Patriotic War of 1812, when the use of elements of architecture from 'post-fire Moscow' became popular in Moscow.

Currently, the building is undergoing maintenance repairs and adaptations for modern use.