It is not exactly known who first owned the estate on Petrovsky (formerly Bogoslovsky) Lane. However, it is known that the stone chambers, built in the shape of the letter P with rich white stone carved window frames and brick vaults, appeared here as early as the 17th century. Perhaps the first owner was Patriarch Adrian, who died in 1700, or the estate could have belonged to the Naryshkins.

In the early 18th century, the estate passed to the steward Dmitry Protasyev, and in 1731 it was acquired by Prince Alexei Yuryevich Trubetskoy. The Trubetskoy family owned the chambers for almost a hundred years. The house was rebuilt according to architectural fashion: initially, its main facade faced the High-Petrovsky Monastery, but then it was moved to the opposite side, to Trubetskoy Lane, which ran parallel to Bolshaya Dmitrovka.

In 1813, Prince A.I. Trubetskoy died near Leipzig. Five years later, his widow Avdotya Semyonovna married the famous Moscow architect O.I. Bove. This marriage caused much talk in society. For example, Princess Turkestanova noted: "Moscow has gone mad, artist, architect, valet, everyone is trying to get married!" On the neighboring plot, the couple began constructing a new house, while the old mansion was sold to Rottmeister L.K. Cherepov. Before the sale, the chambers were rented out, and they housed the famous General M.A. Dmitriev-Mamonov, a participant in the 1812 war, awarded for bravery and one of the founders of the pre-Decembrist organization "Order of Russian Knights."

In the 1840s, the mansion passed to merchant and gold industrialist P.V. Golubkov, who owned an art gallery and a collection of rarities.

After a decade and a half, the house was acquired by the Spiridonov spouses, known philanthropists and guardians of the Spiridonov almshouse. Under them, the mansion was significantly rebuilt and acquired the appearance that has been preserved to this day.

The last pre-revolutionary owner of the estate was the daughter of the Spiridonovs, Major General M.V. Sokol. She also owned a house at Kuznetsky Most No. 3.

After the revolution, the All-Russian Committee for Assistance to Sick and Wounded Red Army Soldiers was located here. Part of the building was converted into residential apartments.

In the late 20th century, the mansion was restored, and the architectural decor in the style of Moscow Baroque was restored with columns, "broken" pediments of window frames, and ornate brackets on the eastern facade.