The Transfiguration Church is located across the Sera River, next to the Assumption Monastery in the Sadovny area. The name of this area dates back to the 16th century when the Tsar's gardens were established here, and the locality still retains an abundance of greenery. A church has existed on this site since the 16th century and was called the Church of the Epiphany 'at the Tsar's court' as it was located near the royal chambers. The census book of 1677 notes that in the new Alexandrov Sloboda, under the city in the fortress of Slobodka Mamonova, there was a church in honor of the Epiphany of the Lord, built of logs.

The stone building of the current Transfiguration Church was erected during the reign of Elizabeth Petrovna, who lived in Alexandrov Sloboda for about ten years and loved this place very much. Upon becoming empress, she ordered the construction of a stone church in 1742-1743 next to the old wooden Epiphany church in honor of the holy prophet Zechariah and the righteous Elizabeth, the parents of John the Baptist. Saint Righteous Elizabeth was the heavenly patroness of Elizabeth Petrovna.

In 1760, the dilapidated Epiphany church was replaced with a new wooden one, and in 1790, a stone chapel in honor of the Epiphany was added to the cold stone church of Saints Righteous Zechariah and Elizabeth from the south side, in memory of the old church. It was consecrated in 1795 by the abbot of the Lukianov Monastery, Hieromonk Macarius. At the request of the parishioners, Bishop Viktor of Suzdal and Vladimir blessed the renaming of the altar in the Zechariah and Elizabeth church in memory of the Transfiguration of the Lord, and to arrange a chapel of Saints Righteous Zechariah and Elizabeth in the refectory. This chapel was consecrated in 1804 by the abbot of the Lukianov Monastery, Hieromonk Nikon. The third altar was consecrated in the refectory on the right side in honor of the Feast of the Epiphany of the Lord.

The bell tower was built in 1804. The largest bell on it weighs 237 poods and was cast in 1836 under the leadership of the priest Joseph Petrovich Klyuchev and church elder Luka Andreyevich Uglkov.

In the past, the Transfiguration Church was the only stone church in the city. During the Soviet era, the church was closed, and in the 1930s, its bell tower and stone fence were destroyed. Miraculously, the cross on the church survived, topped with a crown. The crown was placed on the tops of the crosses of churches associated with crowned persons, as noted by Archimandrite Macarius Mirolyubov. The crown on the cross symbolizes that the church was erected by royal decree with funds from the royal treasury. It is crowned with the Cross of the Heavenly King, reminding of the King of Glory.

Buried near the church are priests Joseph Petrovich and Peter Iosifovich Klyuchev, Peter Kalistov, priest Nikolai Sergiev of the Nativity Cathedral, the wife of priest Sergey Loginovich of the Assumption Monastery, and the mother of Metropolitan Serapion of Kyiv.

In 2010, the church was returned to the church. Inspired by faith and the desire to revive the church, where the Divine Liturgy had been celebrated for many decades, believers gathered in a community, which was led by Priest Nikolai Korneev with the blessing of Archbishop Evlogy of Vladimir and Suzdal.

With the restoration of the community on July 3, 2012, the revival of parish spiritual life and the restoration of the church began. In the partially destroyed building, in a small cleaned corner, molebens began to be held. Although the church is a monument of federal significance, it does not receive restoration funds from the state budget and has no 'fashionable' sponsors. All funds come from donations from parishioners and concerned individuals. Thanks to their support, the church is being restored meter by meter.