The village of Buzhaninovo is located next to a lake of the same name. It existed as early as the beginning of the 15th century alongside numerous villages and hamlets. Initially, the village belonged to Ivan Borzom, then passed to Ulyana, the wife of Ivan Mikhailovich Zvorikin. Ivan's father, Mikhail, traveled to Lithuania in 1490 as an ambassador from Grand Duke Ivan III to King Casimir. In 1543, Ulyana divided the village between her sons Yuri and Fedor. From 1544 to 1547, the estates were sold to the Trinity-Sergius Monastery, which retained ownership of Buzhaninovo until 1764, when the monastery's lands were liquidated.

The history of the church in Buzhaninovo begins simultaneously with the history of the village. In 1543, a separate record of the Zvorikin brothers mentions the church "St. Nicholas the Wonderworker and the chapel of St. John the Ladder, scribe of the leaf." The priest Lavrenty Romanov served in the church. Since the chapel in honor of John the Ladder is no longer mentioned in the 1627 census books, it is likely that the wooden church was destroyed during the Polish invasion and then restored. In 1678, the priest Mikhail Ivanov and deacon Mitka Fedoseev served in the Nicholas church. In 1719, the priest was Adrian Mikhailov, the deacon Ivan Dmitriev, the sexton Grigory Yevdokimov, and the extra deacon Vasily Andreev. In 1734, a new wooden church was built in Buzhaninovo to replace the dilapidated one. It was consecrated by Archimandrite Varlaam, the abbot of the Trinity-Sergius Monastery, in the name of St. Nicholas the Wonderworker. In 1827, the construction of a stone church began with funds from parishioners, and it was consecrated in 1830. The church has two altars: the central one in the name of St. Nicholas the Wonderworker and the side one in honor of the Epiphany of the Lord. The church is an architectural monument in the Empire style.

In 1940, the church was closed, and the bell tower was destroyed. The building was used as storage for the state farm "Trud."

In October 1990, the ruined church building was handed over to the Orthodox community of believers from Buzhaninovo and the surrounding villages. The first rector was priest Nikolai Nedosekin, followed by priest Anatoly Mavlenkov. Since November 1996, priest Nikolai Lyakhov has been the rector of the Nicholas church. At the time of his appointment, the church building was in a deplorable state: half-destroyed, walls covered with moss, and birch trees growing where the dome used to be. The Moscow Diocesan Administration provided the first financial assistance for the restoration of the church by purchasing a set of bells in 1997. A temporary wooden bell tower was erected. Active restoration of the church began in 1997: the roof was repaired, the walls were plastered, and a cross was installed on the dome. On May 10, 1998, Archbishop Grigory of Mozhaisk consecrated the main altar. Since 1999, the reconstruction of the bell tower and the construction of a rectory, where a Sunday school was planned, began. These works were completed in 2004, and the facilities are now used for their intended purpose. The new bell tower was equipped with bells that now call people to reflect on the spiritual. About 15 children study in the Sunday school, learning the Law of God, singing, and drawing. Parishioners, together with the rector, continue to beautify the church. With the help of benefactors, it was possible to install heated floors, improve the territory, and restore the fence. In 2000, a relic of St. Nicholas was given to the church for the feast day. Among the church's relics are also pieces of the Holy Tree and relics of other saints. In 1999, an icon from the 19th century of the Seven Youths of Ephesus, hidden in 1941, returned to the church. Now, on August 17, the day of the memory of the Ephesus youths, an all-night vigil and prayer service are held annually. The rector engages in educational work, distributing gospels and prayer books after services. The parish supports the nearby orphanage.