After World War II, many Russian speakers moved to Boston from Europe. In the 1950s, local emigrants from the Soviet Union decided to build an Orthodox church. In 1953, they found an empty Protestant church, for which the owners asked for a deposit of $900, a significant amount at that time.

The parishioners helped raise the money: each family donated $30, although there were no wealthy members among them; even doctors and teachers had to do unskilled work to survive. The church building was quickly acquired, and the entire congregation got to work. First, they cleaned and removed debris, then they worked on setting up the altar and constructing the iconostasis. One parishioner, a carpenter, made the altar with the help of others. Another, a disabled man without legs, made the first candlestick, memorial table, and carved a cross for the Gospel out of copper. In May 1955, although the work was not yet finished, the church had already become a true Orthodox temple and attracted Russian students from Boston universities.

The former rector of Epiphany Church, Roman Lukyanov, recalled: "Over time, this area of Boston became unsafe due to rising crime. Parishioners were afraid to come to evening services, and the church council decided to find a quieter place for the temple." As a result, the church was moved to another neighborhood.

Today, the parish has several thousand members. These include older emigrants from the USSR who arrived over 30 years ago, their children, and new emigrants who have recently settled in Boston. Among the parishioners are many Orthodox students and faculty from Harvard University, the oldest in the USA. There are also Americans who have converted to Orthodoxy. "We are becoming emigrants in our own homeland," they say. The church has a Sunday school where the Russian language is taught.