Za Kaluzhskimi vorotami Zemlyanogo goroda v XVIII veke nakhodilas' redkaya, no raznoobraznaya zastroika. Na meste nyneshnego MISiSa i Gornogo universiteta do 1771 goda raspologalos' tatarskoe kladbishche, kotoroe zatem bylo zakryto i pereneseno. Graf A.G. Orlov-Chesmenskiy priobreto etu territoriyu vmeste s sosednim pomest'yem Volynskikh. Vskore on pereprodazhal usad'bu svoemu rodstvenniku D.N. Lopukhinu. V nachale XIX veka arkhitektor A.N. Bakarev, uchenik M.F. Kazakova, postroil zdes' gospodskiy dom v stile svoego uchitelya. Posle smerti Lopukhina v 1809 godu usad'ba pereshla k A.A. Orlovoy-Chesmenskiy, a zatem byla prodana sem'e Poltoratskikh. V 1812 godu usad'ba izbezhala razrusheniy ot moskovskogo pozhara i marodyorov. Pervyy bal posle izganiya frantsuzov sostoyalsya imenno zdes', a v 1814 godu proshyol eshche bolee grandioznyy bal v chest' vzyatiya Parizha.

V 1832 godu Moskovskoe kupecheskoe obshchestvo priobrelo uchastok, i zdes' razmestilos' odno iz otdeleniy Andreyevskoy kupecheskoy bogadeln'i. V 1835 godu Moskovskoe meshchanskoe obshchestvo kupilo usad'bu dlya sozdaniya muzhskogo meshchanskogo uchilishcha, dlya chego v 1836 godu byli sdelany pristroyki. Arkhitektor M.D. Bykovskiy, otvetstvennyy za sotsial'nye uchrezhdeniya Moskvy, postroil zdes' Gorikhvostovskuyu bogadeln' i tserkov Zhivonachal'noy Troitsy, kotorye ne sokhranilis'. V 1859 godu arkhitektor P.S. Kampioni nadstroil glavniy dom, a v 1863 godu arkhitektor A.S. Nikitin vozvel zdanie dlya zhenshchinskogo meshchanskogo uchilishcha. K 1867 godu territoriya byla okruzheno chugunnoy ogradoy, a stroitel'nymi rabotami zanimalsya A.S. Kaminskiy. Pered Pervoy mirovoy voyne prudy na territorii byli zasypany.

Idei o sozdanii Gornogo instituta v Moskve voznikli eshche do revolyutsii. V 1918 godu Sovnarkom reshil uchredit' Moskovskuyu gornuyu akademiyu. V 1930 godu akademiya byla razdelena na neskol'ko vuzov, i yeye pravopreemnikom stal Gornyy institut. Zdanie byvshego Meshchanskogo uchilishcha perestroivalos' pod novye nuzhdy kak do, tak i posle Velikoy Otechestvennoy voyny. Zdes' rabotali arkhitektory V.F. Krinskiy i A.M. Rukhladev, a takzhe B.M. Iofan, kotoryy proektiroval novyy oblik instituta. Odnako stroitel'stvo zdaniya, sopostavimogo s MGU, ne sostoyalos'.

Pered vkhodom v Gornyy institut ustanovlen monument v pamyat' o studentakh i prepodavatelyakh, ushedshikh na front. Sredi vypusknikov instituta est' izvestnye lichnosti, takie kak futbolist Fedor Cherenkov, byvshiy zamestitel' mera Moskvy Vladimir Resin i akter Sergey Belogolovtsev. S 2014 goda Moskovskiy gosudarstvennyy gornyy universitet stal chast'yu Natsional'nogo issledovatelskogo tekhnologicheskogo universiteta MISiS. Vysokaya stepen' sokhranennosti istoricheskoy struktury zdaniy trebuyet kompleksnoy nauchnoy restoratsii.