Vasily Nosov, the head of the family business, built this two-story house in the early 1880s on a stone foundation from the 1870s, designed by architect P. Shchegolev. A large garden adjoined the house.

When his son Vasily married Yefimiya Ryabushinskaya, the elder Nosov moved to another house on the estate, splitting the garden in half, and left the mansion to the young couple. Emancipated Yefimiya became the true mistress of the house, striving to turn it into an exquisite salon of the 'Silver Age.' She dreamed of having outstanding contemporary Russian artists create something special in this house. In 1907, Ivan Zholtovsky, a future classic of Soviet architecture, was invited to update the interiors. The reconstruction of the house also involved Lev Kekushev and engineer A. Ageenko, who added the left wing. The exterior of the house has not changed since the 1910s.

Zholtovsky created a grand marble hall inside with Corinthian columns and large mirrors. In 1911, for the decoration of the walls of the Nosov's dining room, V. Serov was invited, who created 29 sketches on the theme 'Diana and Actaeon,' but he did not manage to complete the work due to his sudden death. His work was continued by artists S. Sudeykin and N. Sapunov. The grand staircase was designed by M. Dobuzhinsky in 1912-1913, after visiting Italy to study the originals. His fresco was made after the frescoes of the Palazzo Medici in Florence. In 1940, the fresco was painted over, but was initially protected with paper, and when the covering was removed in the early 1970s, it remained in excellent condition.

The mansion in Moscow began to be called the 'Palace of Cosimo de' Medici,' and Yefimiya Nosova was referred to as 'the mistress of a fashionable salon that attracted prominent artists and writers.' Nosova planned to donate the mansion with its artistic contents to the city of Moscow and turn it into a museum.

In the autumn of 1917, fearing requisitions, Nosova transferred all artistic valuables to the Tretyakov Gallery and soon left for abroad. In her house, a free canteen for 2,500 Red Guards and workers was already operating in 1917.

Until 1935, the nationalized Nosov house remained unchanged, as it housed the Proletarian Museum of the Blagush-Lefortovo district. Later, it was repurposed as a district Palace of Pioneers, redesigned, and the mirrors and chandeliers were taken away. From 1962 to 1997, the house housed the 'Local History Museum of the Pervomaisky District.' Since the late 1990s, the house has become practically inaccessible. The fate of the 'Silver Age' interiors remains unclear; it is known that part of the frescoes and decorations have been lost.