A small estate adjacent to the vast lands of G.P. Gagarin, in the late 18th and early 19th centuries belonged to Marfa Protkova, the wife of a collegiate assessor. The main house of the estate, a wooden single-story building with mezzanines on a stone foundation, was built in 1809 and was located along the Earth Rampart.

Surviving the fire of 1812, the house acquired Empire features in 1815, corresponding to the time. Architect O.I. Bove adorned it with rich stucco and a massive Tuscan portico that protruded forward, forming a terrace.

In the second half of the 19th century, the house passed into the ownership of the Konshin family: merchant and hereditary nobleman Nikolai Nikolaevich and his wife Olga Nikolaevna, born Dobrynina. They had many children, including from N. Konshin's first marriage. In 1881, the owners carried out a major renovation, partially replacing ceiling beams, crowns, and window frames.

In 1897, a children's hospital named after Sofia opened on the neighboring plot. A year later, the Konshin sons sold their land to it. From that moment, the estate's gates became the main entrance to the hospital, and the wooden house became part of the hospital's property and the residence of the chief physician. Notable doctors N.V. Yablokov, E.A. Pokrovsky, and N.F. Filatov, whose name the hospital received in 1922, lived here.

During the 1905 revolution, the house was damaged by artillery fire from Presnya.

In 1985, restoration of the house began, which continued with interruptions for several decades. Special attention was paid to restoring the unique interiors. The original enfilade layout, partial ceiling stucco, antique tiled stoves, and columns have been preserved. Thanks to the meticulous work of restorers, it was possible to recreate the original decor: green, raspberry, and golden-ochre drawing rooms, an oak staircase, and magnificent stucco. In the restored house, the Filatov Hospital plans to open a museum.