The two-story building, erected in 1900, is part of the historical ensemble of the Brotherhood Society houses in Lefortovo. Originally, this ensemble included six houses that provided free or low-cost apartments for widows and orphans, also known as widow houses.

These houses were built in the late 19th and early 20th centuries with funds raised by the society founded by Princess Nadezhda Trubetskaya in the 1860s. This organization, which included many notable residents of the city, assisted low-income Muscovites by providing them with housing.

The widow houses of the Brotherhood Society were located in various districts of the city, such as Mokhovaya Street and Plyushchikha. The buildings with affordable and free apartments on Hospital Street were named after their benefactors.

The house named after A.V. Shcheglyaeva was designed by architect Ivan Mashkov in the neo-Russian style, characterized by the use of elements from ancient Russian and Byzantine architecture. Ivan Mashkov (1867, 1945) was a Russian secular architect, restorer, and researcher of Russian architecture. He worked in neo-Russian and neoclassical styles, as well as in the Art Nouveau style. His projects include the apartment building of M.V. Sokol on Kuznetsky Most (house 3) and the mansion of E.M. Pautynskaya on Malaya Dmitrovka (house 16). Mashkov also participated in the restoration of the Smolensky Cathedral of the Novodevichy Convent and the Assumption Cathedral in the Kremlin.

The main facade of the building is made of pink brick and decorated with white decorative brick of non-standard shapes and sizes. The windows are framed with triangular and shaped lintels, half-columns, melons, and weights. The facade also features a frieze with an ornament, at the bottom of which are hanging stepped teeth.

On the first floor of the building, there were 15 rooms, and on the second, 16. Both floors had a kitchen, corridor, entrance hall, and two bathrooms. During the Soviet era, the former widow house continued to be used as residential, housing apartments. Later, the building was converted into office space.