Lepyokhin Lane, previously known as a alley, connected Pokrovka Street with Kazarmenny Lane. In the late 18th century, part of it was built up, and it became a dead end, although it continued to be marked on maps as Alley Tupyik, Tupy or Pokrovsky Alley.

The oldest building in Lepyokhin Lane, the estate house of the Andronov merchants, was built in the late 18th and early 19th centuries, before the fire of 1812. The Andronovs, who owned the estate since the early 18th century, were successful merchants, running a tavern near the Pokrovskaya Tower of the White City, and after the wall was demolished, they established an inn with a forge in its place. Later, a hotel was built near the Pokrovsky Gates.

In the second half of the 19th century, the house acquired its current appearance: the facade was redesigned in an eclectic style with elements of classicism. The first floor is decorated with rustication, while the second is adorned with Ionic pilasters. The center of the facade is highlighted by a balcony on brackets with an arch beneath it, and the door opening is decorated with a cornice-like sandrik.

In 1868, the estate was purchased by Elizaveta Milyukova, who established a clinic here in memory of her uncle Sergey Vasilyevich Lepyokhin. The clinic was funded by Milyukova's capital and fees from wealthy patients. In 1878, it became part of the institutions of the Alexandrovskaya community “Utolimaya Pechali,” patronized by Princess Natalia Borisovna Shakhovskaya.

In 1890, a church dedicated to Sergius of Radonezh was built on the clinic's territory in the neo-Russian style. In the early 20th century, two more buildings appeared: a two-story hospital building and a four-story apartment house, the income from which supported the clinic.

In 1906, the clinic was transferred to the city administration, which decided to create a maternity home based on it, placing it in the four-story apartment building. The maternity home opened in 1907, with its first chief physician being obstetrician-gynecologist Grigory Lvovich Grauer. In 1910, a hospital for postpartum patients with an outpatient clinic was opened at the maternity home, named after L.I. Timister.

In 1929, the maternity home and hospital were transformed into the Institute for the Protection of Motherhood and Infancy, later renamed the Moscow Regional Scientific Research Institute of Obstetrics and Gynecology (MONIAG), which is still located here today.

The historical complex of the maternity home and hospital has been preserved in its original form, except for the Sergius Church, which was decapitated during the Soviet years and adapted for the needs of the institute.