Spaso-Andronikov Monastery, formerly a male monastery of the Russian Orthodox Church, is located on the left bank of the Yauza River. It was founded in 1357 by Metropolitan Alexius as a metropolitan monastery and named after the first abbot Andronicus, a disciple of Sergius of Radonezh. The monastery is now situated in Moscow, near Andronievskaya Square.

The monastery has existed for over six centuries, surviving numerous destructions, fires, and other trials. The Spassky Cathedral, the oldest church in Moscow, is considered one of the oldest buildings in the city outside the Kremlin, as the Church of the Nativity of the Virgin in the Kremlin has only partially survived.

In 1960, declared by UNESCO as the year of the Russian icon painter Andrei Rublev in honor of the 600th anniversary of his birth, a museum of Andrei Rublev opened in the monastery. Since 1985, it has been known as the Central Museum of Ancient Russian Culture and Art named after Andrei Rublev. The museum's collection includes works by icon painters from the circle of Dionysius and Andrei Rublev, as well as other masterpieces, including a 13th-century icon of the Almighty.

In 1989, the Spassky Cathedral was consecrated, and services resumed there. In 1993, unknown burials were discovered under the altar of the cathedral, two of which likely belong to the monks Andrei Rublev and Daniil the Black.