The cathedral of Archangel Michael in the monastery was destroyed in 1408 during another capture of the city, this time by Edigei, and was soon restored. In 1535, there was a wooden church of Archangel Michael with a chapel of the Prophet Elijah, built with funds from Grand Duke Vasily Ivanovich. In 1560, the first stone church was erected, funded by Prince Ivan Mikhailovich Kubensky. In 1636, the church was surrounded by porticos on three sides, and by the end of the 18th century, the dilapidated building was dismantled. The construction of a new cathedral began in 1792 with funds from the townspeople and was completed in 1806. The interior finishing continued for about two more years, and in 1808, Bishop Xenophon Troepolsky from Vladimir consecrated the new cathedral.

Despite the time of construction, the church retains features of mid-18th century architecture, with some elements even from the 17th century. The high, column-free building with five domes is adorned with rustication, carved cornices, and friezes. The cathedral housed an icon of Archangel Michael, which in 1812 was handed over by the monastery's abbot Nikon to the 5th regiment of the Vladimir militia. The icon went through the entire war and returned to the monastery in 1814. Many abbots are buried in the Archangel Michael Cathedral, including the son of the monastery's founder, schema-monk Prince Dmitry Svyatoslavich, who died in 1269. The church still preserves two ancient monastery icons, revered as miraculous. During the Soviet era, the interior decoration of the cathedral was destroyed, and the building was used as exhibition halls for the museum, which still exists there today. However, a few years ago, by agreement with the Vladimir diocese, services were resumed in the church.

During the Soviet era, the monastery was closed, and the archimandrite's building was repurposed as a museum thanks to the efforts of the famous architect and restorer P.D. Baranovsky. Various institutions were placed in other buildings, for example, a mill was set up in the cathedral. Over time, the museum occupied the entire monastery complex and continues to remain there. Its exhibitions reflect the entire history of Yuriev Opole, with a collection of numerous icons, paintings, art objects, and household items. Visitors can also climb the bell tower to see the monastery from above and enjoy its views.