History has not preserved the names of the talented architects who created this remarkable architectural monument. The Annunciation Cathedral resembles the Trinity Cathedral of the Sergiev Lavra but was built slightly later, at the end of the 15th and beginning of the 16th centuries, likely in the final years of the reign of Grand Duke Ivan III. Later, Vasily III, the son of Ivan III, added a chapel dedicated to Saints Constantine and Helena in the lower church of the Annunciation Cathedral, dedicated to the heavenly patroness of his second wife, Elena Glinskaya. Some researchers believe this occurred around 1530 when Vasily and Elena visited the Kirzhach Monastery after the birth of their long-awaited son, Ivan IV.

The Annunciation Kirzhach Cathedral, like the Trinity Cathedral of the Lavra, belongs to the monuments of Moscow architecture due to its architecture, size, harmony of spatial relationships, and certain decorative elements. Its architecture is simple yet majestic, creating an impression of elegance and artistic integrity. The cathedral building stands on a high plinth, where, on the southern side of the altar, the relics of St. Roman rested in a copper tomb. The tomb was engraved with a troparion and kontakion to St. Roman. The top of the tomb was adorned with an image of the Saint, while the gravestone depicted the Life-Giving Trinity. Above the tomb rose a gilded canopy with carvings on four columns.

Currently, in the lower church of the Annunciation Cathedral, there is a temple whose altar is consecrated in honor of St. Roman of Kirzhach, and his relics rest there as well.

According to an inventory of church property from the 19th century, at that time, the iconostasis of the Annunciation Church was wooden, three-tiered, with 47 icons, two of which, the Smolensk Icon of the Mother of God and the Annunciation of the Blessed Virgin Mary, were local and adorned with expensive silver vestments. The lower tiers of the iconostasis were decorated with 12 gilded columns with carvings.

In 1963-1964, the Annunciation Cathedral and the Church of the All-Merciful Savior were restored according to a project developed under the guidance of architect I.A. Stoletov in the scientific restoration workshops of Vladimir. Over two years of work, a new dome and cross, covered with shingles, were installed on the cathedral. Due to deterioration and in accordance with the concept of restoring churches to their original appearance, the second floor of the gallery connecting the cathedral with the Savior Church was dismantled, stairs were built, and door and window openings were repaired. No internal work was carried out; the building was limited to external whitewashing. After that, it remained abandoned for another 20 years.

In 1983, the city authorities of Kirzhach planned to open a museum in the Annunciation Cathedral. However, due to violations of technology during repair and restoration work in the 1980s and 1990s, the monastery churches ended up in an emergency state, and the authorities abandoned their plans. In 1990, the Annunciation Cathedral was returned to the Russian Orthodox Church.