One of the well-known mansions of pre-revolutionary Rostov-on-Don is the house of Eva Spielrein, built in 1897. This building has the status of a cultural heritage site of regional significance. The Spielrein family lived there with their children, and the direct owner was the dentist Eva Markovna Spielrein, who also practiced dentistry there. In this house, the childhood and youth of her daughter Sabina Nikolaevna Spielrein, a future renowned psychoanalyst, and her sons: mathematician Yan Nikolaevich, biologist Emil Nikolaevich, and psychologist Isaac Nikolaevich took place.

The three-story building has a U-shape and is located along the red line of Pushkinskaya Street. In the inner wings facing the courtyard, there were originally residential premises rented out. The courtyard also housed an ice house, a carriage house, and a stable.

The architect of the building harmoniously combined elements of Renaissance, Baroque, and Classicism in its architecture and facade design. The central part of the main facade is highlighted by a rustication with a two-tiered loggia decorated with pilasters. On the side parts of the facade, in the spandrels, there are pilasters with Eastern ornamentation. The first floor of the building is rusticated. In the center of the facade are two arches (the main entrance and the entrance to the courtyard), adorned with keystones featuring lion masks. On the entablature of the facade, there are cartouches, with the year of the house's construction, 1897, indicated on the central one. The facade decoration also features profiled window frames, archivolts, and decorative brackets.

Eva Spielrein used the building not only for living but also as a rental property. Before the start of World War I, the Belgian consulate was located there, and one of the apartments was rented by the Turkish consul. Among other tenants were sworn attorneys, engineers, and merchants, making the house a prestigious place to live.

After the arrival of Soviet power, the rental house was confiscated, and the Spielrein family was left with a small room under the main staircase, where Eva Markovna lived until her death in 1922. During World War II, the roof of the house was partially destroyed, but after the war, it was restored and reoccupied. Currently, the building houses the memorial museum of Sabina Spielrein.

In 2002, a memorial plaque was installed on the facade of the building, made by Rostov sculptor B. N. Kondakov, with the inscription: "In this house lived the famous student of C. G. Jung and S. Freud, psychoanalyst Sabina Spielrein 1885, 1942."