The buildings on Romanov Lane, including a residential income house from the third quarter of the 19th century (building 1) and the adjacent courtyard wing (building 2), are significant historical structures in Moscow. Both buildings were designed by architect V.V. Belokryltsev, one of the founders of the Moscow Architectural Society.

In the wing, a memorial museum-apartment was established in 1942 as a branch of the K.A. Timiryazev Biology Museum. This was done by the decision of the Soviet authorities (VTSIK) to preserve the study and scientific legacy of K.A. Timiryazev. On April 27, 1946, the museum was transferred to the management of the K.A. Timiryazev Moscow Agricultural Academy.

The family of K.A. Timiryazev preserved the apartment as it was during his lifetime, and his son personally handed it over to the museum. The museum-apartment exhibition includes five rooms, including living quarters, a library, and the scientist's study. In 1958, the building was renovated, updating all communications and partially reconstructing the interiors to increase exhibition space.

The museum is protected by the state as a monument of federal significance.

Professors and teachers of Moscow University lived in the income house, while in the wing, built simultaneously with the house, the biologist, agronomist, and professor of Moscow University, Kliment Arkadyevich Timiryazev (1843-1920), resided from 1899 to 1920. During his lifetime, notable figures of the Russian intelligentsia frequently visited, including writers L.N. Tolstoy and A.M. Gorky, artists I.I. Levitan and V.D. Polenov, physiologist I.P. Pavlov, composer S.I. Taneyev, publisher and philanthropist I.N. Knebel, and others.