In the mid-17th century, two estates belonging to members of the Pushkin family, cousins Grigory Grigorievich and Boris Grigorievich Pushkin, were located here. In 1763, these holdings were united under the management of Alexander Artemievich Zagryazhsky, whose granddaughter Natalia became the mother of Natalia Nikolaevna Goncharova.

In 1786, the merchant Pyotr Mikhailovich Gusyatnikov, known in the 18th century, purchased the estate from the Zagryazhskys. He was a wealthy 'notable citizen', a representative of the upper merchant class, and along with his partners owned the wine monopoly in Moscow, as well as cloth and hat factories in Kozhevniki. His company established the customs border of Moscow, the Kamer-Kollegsky Val. The descendants of Gusyatnikov, including the poet Apollon Maikov and the Decembrist Mikhail Fedorovich Orlov, transitioned into the nobility. The old Gusyatnikov house hosted the famous Moscow boarding school of Kister in 1827 and 1828, where the future historian and professor of Moscow University Timofey Granovsky studied. In the 1860s, the boarding house of R.I. Zimmerman was located here.

In 1857, the estate passed to the St. Petersburg merchant Yegor Mikhailovich Skvortsov, who built a new stone house. There were rumors that he used stones from the collapsed Kremlin wall or the Bolshoy Kamenny Bridge. In 1859, the newspaper 'Moscow Provincial Gazette' reported that Skvortsov built a large income-generating house at the corner of Mokhovaya according to the design of architect Nikolsky. The facade of the building was beautiful, with shops on the first floor and apartments above. The Commercial Court was also located in the house, where A.N. Ostrovsky served.

In 1899, the Russian Society for the Insurance of Capital and Income acquired the old estate at the corner of Vozdvizhenka and Mokhovaya and demolished the old buildings to erect a new one designed by architect V.V. Shaub. The house was built in the style of German modernism with baroque decor and naturalistic images. The corner turret with a dome emphasized the intersection of the streets and echoed the Trinity Tower of the Kremlin. The first floor was rented out for shops, while the other floors housed the 'Peterhof' hotel.

Part of the house was occupied by expensive apartments. In December 1905, one of them was rented by A.M. Gorky and his common-law wife M.F. Andreeva, where Serov painted the famous portrait of the writer. In 1913 and 1919, the famous tenor Leonid Vitalievich Sobinov lived here.

After 1917, the secretariat of the Central Committee of the VKP(b) was located here, and later the 4th House of Soviets, where party officials such as A.I. Rykov, N.A. Semashko, and others lived. This building housed the institutions of the CEC, as well as the reception of the chairman of the Presidium of the Supreme Soviet M.I. Kalinin.

Currently, the Reception of the State Duma is located on the Vozdvizhenka side, while on the Mokhovaya side, there is the Business Center 'Business House Mokhovaya.'