In the nineteenth century, Rostov-on-Don became one of the most developed cities in southern Russia, leading to an increase in the number of Catholics in the city. As a result, in the second half of that century, the first Catholic church dedicated to the "Last Supper" was built in Rostov. By 1898, its parish had about 3000 members and continued to grow.

At that time, various Christian denominations coexisted peacefully in prosperous Rostov-on-Don, and no one could have imagined that soon all Christians would face brutal persecution. In 1920, the Bolsheviks finally seized the city and began to change its life at their discretion, closing and destroying temples. Among the destroyed buildings was the beautiful Catholic church.

Only in 1992 was the parish of the destroyed church revived, and in October 1993, a wooden chapel was gifted to it. By spring 1999, the foundation of a new church and spiritual and charitable complex was laid, with construction completed in 2004. On September 19 of the same year, the consecration of the temple took place, conducted by the bishop of the diocese of Saint Clement in Saratov, Clemens Pikkel. Soon, the spiritual and charitable complex began operating, offering a video library, music salon, and computer room. The parish now has over 300 members.