Between two Three Hills and one Novovagankovsky Lane lies a church with a complicated fate. Known since the 1620s-1630s, it has changed its name multiple times and has been rebuilt several times. Originally wooden, built by parishioners from the Tsar's Kennel, it was reconstructed in stone in 1762 and 1775. Since then, the church has expanded, with additional chapels added, and in 1860, a bell tower and refectory were built, increasing the building's area by two and a half times.

The parishioners and benefactors of the church were wealthy individuals, including the Prokhorov factory owners, who owned the neighboring Three Hills manufactory. Due to the chaotic nature of previous constructions and the growing number of parishioners, a new reconstruction was necessary. This was carried out from 1900 to 1902 based on the project of architect Georgy Alexandrovich Kaiser, funded by major merchants Kopeykin-Serebryakov, who lived in the parish. After the reconstruction, the church was consecrated anew in 1902, but the work was only completed in 1908.

In the early 20th century, most parishioners were workers from the Three Hills manufactory. During the tumultuous years of 1905 and 1917, they guarded the cathedral, which was at the center of revolutionary events in Presnya, ensuring that the church was not damaged or looted.

In the 1920s, one of the church's regents was Alexander Vasilyevich Alexandrov, the author of the USSR anthem.

The church was closed in 1928. It was decapitated, openings were made in the walls, and the top of the bell tower was dismantled. The disfigured building housed a pioneer house/cultural center named after Pavlik Morozov. The lane, previously called Nikolsky due to the church, was also renamed in honor of the pioneer.

The church was returned to the faithful in 1992. Restoration work was carried out in 1991 and 2000 based on the project of G.A. Kaiser. A Sunday school, a biblical college, a medieval culture historical reconstruction club, and a contemporary art center "ArtEria" operate at the church.