Nova Mysh has been known since the 16th century as a settlement on the Warsaw road. At different times, it belonged to the Khadkevich, Sinyavsky, Yuditsky, Masalsky, and Neselovsky families. In 1859, a church was built in the central square of the village with funds from the Russian Empire and local peasants.

The wooden Transfiguration Church in Nova Mysh reflects the features of ancient Russian cult architecture. It is a centralized cross-domed church located on a high stone pedestal. The main cubic volume of the building is covered with a four-pitched roof, crowned with five octagonal two-tiered drums topped with tent-like spires, on which bulbous domes are situated. One of the drums houses a bell tower with four bells. The side chapels are completed with two-pitched shields and have paired window openings with colored stained glass. The facades are adorned with wide corner pilasters and a cornice, as well as pierced with high rectangular windows with ornamental finishes.

The interior is dominated by the central space of the prayer hall, over which rises a light octagonal drum supported by massive beams. The side chapels, apse, and narthex are connected to the main volume by wide openings with beveled upper corners. The interior decor features rectangular and shaped panels in the frieze section. The apse is highlighted by a single-tier iconostasis with a central keel-shaped pediment made of wood in the second half of the 19th century.