In the village of Plyuskovo, there once stood one of the largest estates in the Kaluga province. In the mid-18th century, Nikita Alexeyevich Muromtsev inherited the village of Dudino in the Medyn district from his father, where a merchant's court was located. He settled in this village, which was the ancestral estate of his grandmother Avdotya Ivanovna Plyuskova. The village was called Dudino, Plyuskovo, or Muromtsevo. In the early 19th century, the estate passed to Alexey Nikitich Muromtsev, who built a stone church with a bell tower in Plyuskovo in 1820 in honor of the Nativity of the Blessed Virgin Mary. One of Alexey Muromtsev's granddaughters, Ekaterina Nikolaevna, married the Smolensk nobleman Deryuzhinsky, with the wedding taking place on June 4, 1854, in the local church. In the 1870s-1880s, the estate passed to the Deryuzhinskys, likely in co-ownership with the heirs of Arkady Alexeyevich Muromtsev, the younger son of Alexey Nikitich. The Deryuzhinskys remodeled the estate, adding a dairy farm building to the west of the main house. In 1905, a church-parish school was built on the estate, where the post office now stands. The parish of the church included the village of Dudino (Plyuskovo), the villages of Tsyganovka, Pakhomovo, Smagina, totaling 696 people in 1911. Among the priests of the church were Alexey Alexandrovich Sokolov and Timofey Stepanovich Vorontsov.

After 1917, the estate housed a commune and later a collective farm. The church was closed and used for economic needs, gradually falling into disrepair. On August 13, 1998, the diocese appealed to the governor to return the vacant church in Plyuskovo for restoration and the resumption of services. On May 26, 2000, the church was handed over to the Kaluga diocese according to the order of the Ministry of Culture of the Russian Federation and the Ministry of State Property dated August 18, 1999. Currently, the church is being restored: the facade has been partially finished, and internal restoration work is underway.