The history of the estate on Pokrovka begins in the 1780s. In the mid-19th century, it belonged to A.F. Marku, a representative of the famous family of "Moscow Germans" Vogau and Markov. In the 1860s, Dmitry Petrovich Botkin acquired the estate, registering it in the name of his wife Sofia Sergeyevna. The Botkins, known in Moscow as tea merchants, were a respected merchant family. Dmitry Petrovich had been passionate about collecting art since his youth and became a recognized expert in this field. The writer P. D. Boborykin noted that Botkin carefully selected paintings, avoiding fashionable and eccentric subjects. Initially, the collection, consisting mainly of Western European works, was housed in a building on Petrovverigsky Lane, but was later moved to Pokrovka.

In 1867, the estate was rebuilt in the Russian style by architect A. S. Kaminsky. A feature of the project was the arches preserved in the courtyard, which visually connected with the arches of the Apraxins-Trubetskoys house on the opposite side of the street, creating an interesting enfilade. The estate also included a cow shed, a chicken coop, and cellars for provisions.

In the two-story building, Botkin organized an art gallery with three halls, open for visits on certain days. The collection included works by famous Western European and Russian artists such as Ch. F. Dobigny, J. B. K. Corot, K. Troyon, A. A. Ivanov, I. N. Kramskoy, and V. D. Polenov. The gallery was visited by L. N. Tolstoy and A. A. Fet.

After Dmitry Petrovich's death, the collection was divided: part went to France, while another enriched the collection of the Museum of Fine Arts on Volkhonka after the revolution. In the early 20th century, the estate belonged to his son Peter Botkin. During the Soviet era, it housed communal apartments, and currently, it accommodates various offices and cafes.