The estate on Novokuznetskaya Street, previously known as Kuznetskaya Street due to the settlement of blacksmiths located here, was built in the first half of the 19th century after a fire. It was a typical city estate of that time: a two-story main house located along the street, with single-story wings on the sides and a garden in the courtyard.

Until the end of the 19th century, the estate was owned by the Tselibeev merchant family from Maloyaroslavets, who belonged to the Rogozhskaya Old Believer community. They were second-guild merchants engaged in the tea and sugar trade in Moscow.

At the turn of the 19th and 20th centuries, the estate was acquired by Timofey Gennadyevich Karpov, a hereditary nobleman and titular adviser, the son of the famous historian G.F. Karpov. Through his mother, he was connected to the Morozov merchant dynasty. At his request, architect A.P. Vakarin reconstructed the main house in 1900, transforming it into a mansion in the eclectic style with an original roof and classical decorative elements.

After marrying Maria Dmitrievna Lepeshkina, Karpov transferred the house to her name, and she remained the owner until 1917. The Karpovs were actively involved in charity work, being members of the Moscow Charity Society and other organizations under the patronage of Grand Duchess Elizabeth Feodorovna.

After the October Revolution of 1917, the Karpov estate was nationalized, and they moved to a house at Bolshaya Ordynka, 41, which had previously belonged to T.G. Karpov's brother, Fyodor Gennadyevich. In the last years of his life, Timofey Gennadyevich was the elder of the Church of the Iveron Mother of God on Bolshaya Ordynka. In 1929, he was arrested and sent into exile, where he died three years later.

After nationalization, apartments were arranged in the mansion on Novokuznetskaya. One of them was occupied by the famous architect Alexey Nikolayevich Dushkin in 1935 and 1947, the author of many buildings in Moscow, including the Children's World and the skyscraper at Krasnye Vorota, as well as several metro stations and railway stations.

Later, the mansion was repurposed for diplomatic needs, and it now houses the Embassy of Mali.