The house was built in 1820 by Pelageya Vasilyevna Ketcher, the wife of a naturalized Swede and owner of a surgical instruments factory, Christophor Yakovlevich Ketcher. Their son, Nikolai Christophorovich Ketcher, became famous for his translations of Shakespeare's works.

Previously, the plot on Stara Basmannaya belonged to the Khomutovs, whose house burned down in the Moscow fire of 1812. In 1819, they sold it to the Ketchers.

A wooden one-story house with mezzanines was constructed on the site. The yard housed a servant's wing with a stable, a carriage shed, and a cellar. The house was surrounded by a garden. The log cabin was clad with boards and plastered, while the facade resembled empire-style stone buildings with columns and stucco.

In 1824, the poet Vasily Lvovich Pushkin, uncle of Alexander Pushkin, rented the house. Vasily Lvovich was a well-known figure in Moscow, actively participating in its life. His hospitable home was frequented by poets and writers such as Pyotr Vyazemsky, Denis Davydov, Adam Mickiewicz, and others. He maintained friendly relations with N.M. Karamzin, V.A. Zhukovsky, and K.N. Batyushkov.

A document regarding the rental of the house by Vasily Lvovich Pushkin is kept in the Central Historical Archive of Moscow. It states that he rented the house for a year starting September 1, 1824, for two thousand rubles. Pushkin agreed to keep the house clean and in good repair, and in case of fire, to compensate for damages.

The rental agreement was extended, and the Pushkin family lived in the house until 1827. Alexander Pushkin first visited his uncle on September 8, 1826, after meeting Emperor Nicholas I. He often visited Vasily Lvovich, calling him his "Parnassian father."

P.V. Ketcher sold the house to Elizabeth Karlovna Tsenker in 1828, after which it changed several owners. By the end of the 19th century, the facade of the house was updated, and during the Soviet era, the building was renovated. It housed communal apartments and various institutions.

In 1962, a memorial plaque was placed on the facade, informing about Alexander Pushkin's visits. In 1974, the house was placed under state protection.

In 1998, a resolution was adopted to preserve the house and create a branch of the State Museum of A.S. Pushkin in it. The house was closed for reconstruction, and a comprehensive restoration was carried out in 2012-2013. The interiors and layout of the 19th century were restored, and the appearance of the facades was preserved.

The basement now houses a vestibule, cloakroom, ticket office, and exhibition hall. The first floor has restored parquet, and the walls and ceilings have been renovated. The building is equipped with modern systems and is accessible for people with limited mobility.

In 2013, the house became a laureate of the competition for the best project in the field of cultural heritage preservation. The Museum of Vasily Lvovich Pushkin opened on June 6, 2013, as a branch of the State Museum of A.S. Pushkin.