The commemoration of Lenin in Simbirsk began with the installation of memorial plaques on the Ulyanov family house on Moscow Street. In 1918 and 1926, three plaques appeared on this house, the last of which, created by artist A. A. Plastov, has survived to this day. The marble plaque reads: "Here lived Vladimir Ilyich Ulyanov-Lenin in 1878 and 1887," and features a bas-relief of Lenin.

In 1923, the Ulyanov house was nationalized and the Museum of the Revolution named after V. I. Lenin was opened there. The museum consisted of four sections that highlighted Lenin's life and activities, the history of the revolutionary movement in the province, the October Revolution, and the Bolshevik Party.

In March 1928, a commission was established to restore the Ulyanov house to create an exhibition reflecting the family's life in the 1870s and 1880s. The museum reopened in its new format on November 7, 1929.

In the early 1930s, the estate underwent reconstruction. To ensure the long-term preservation of the house and buildings, conservation work on the wooden structures was carried out in 1946 and 1947. The museum reopened on August 24, 1947, and has existed in this form to this day.

On November 2, 1941, a branch of the Central Museum of V. I. Lenin opened in the southern part of the estate, in the former mansion of Baron H. G. Stempel, featuring an exhibition about Lenin's life and activities. This is now the A. A. Plastov Museum of Modern Art located at 51 Lev Tolstoy Street.

On December 27, 1973, by decree of the Presidium of the Supreme Soviet of the USSR, the V. I. Lenin Memorial Museum in Ulyanovsk was awarded the Order of the October Revolution for its significant work in promoting Lenin's ideas and the communist education of the working people.