Once wooden structures stood on this site, and then a stone house appeared, belonging to the merchant's son Mikhail Ivanovich Prigodin. Before the 1812 war, the owner became Varvara Dmitrievna Poluektova. In the late 1830s, she sold the property to the titular councilor Ivan Danilovich Loris-Melikov, who decided to rebuild the house. For this, he invited architect Mikhail Dorimedontovich Bykovsky, who studied in the family of Italian architects Zhilyardi. Among his classmates was the Italian Konstantin Lvovich Minelli, whose sister Emilia became Bykovsky's wife.

Family happiness brought success in his career. In 1836, Bykovsky headed the architectural school and actively worked in Moscow. His love for his wife remained unchanged, but in 1841 Emilia died during childbirth of their son Konstantin. In her memory, Bykovsky built the chapel of Saint Emilia in the Catholic Church of Peter and Paul. At this time, he also received an order for Loris-Melikov's house in the same alley where the church was located.

This two-story house in the late classical style was meant to be a worthy monument to his wife. The first floor is adorned with rustication and almost square windows, giving the building a monumental appearance. The second floor, the main one, stands out with high semicircular windows with carved wooden frames, which are almost the only ones preserved in Moscow.

The interiors of the house are luxurious and elegant, like a true palace: stucco and painted ceilings, carved doors, marble columns and floors, sculptures, and relief friezes. A staircase made of Kaslinsk casting leads to the second floor. Behind the house is a semicircular stable building, forming a cozy courtyard of the estate.

The house on Milyutinsky Lane, created by Bykovsky, combines intimacy and splendor, festiveness and coziness.

In the 1870s, the house passed to other owners, and then an attic floor appeared. In 1891, the estate was purchased by Sofia Ivanovna Ekizler, who rented out the premises.

In 1928, communal apartments were arranged in the house, which later changed to office spaces and a dormitory for an institute. The building deteriorated, and almost the entire interior was destroyed. In 1988, the house was transferred to the All-Russian Cultural Foundation, which conducted a thorough restoration, restoring the architecture and decor of the interiors.