In the 17th century, the street known as Granatnaya got its name from the Granatny Courtyard, a military factory that produced artillery shells and grenades. After the fire of 1712, the courtyard was relocated, and from the mid-18th century, the street began to be populated with noble estates. After the 1812 war, many damaged buildings, especially wooden ones, were restored. In 1949, the alley was renamed Shchuseva Street in honor of the famous Soviet architect, as the Union of Architects of the USSR was located here. In 1993, the alley was returned to its historical name.

The corner house at number 2/9 was built in 1902 for merchants Mikhail and Nikolai Armyansky. In 1897, they acquired a plot at the intersection of Spiridonovka Street and Granatny Alley. The house was constructed in two stages: in 1899, a three-story stone building in eclectic style was built according to the design of architect G.A. Kaiser, and in 1902, architect V.A. Velichkin erected a massive four-story building in the Art Nouveau style. In the late 1930s, the house was raised: the four-story part received another floor, while the three-story part received two.

Until 1917, the owners' family lived in the house. N.P. Armyansky was a member of the Russian Photographic Society, while his brother M.P. Armyansky was a founder of the Skiing Lovers Society. Apartment 21 housed a private school run by A.F. Armyanskaya. Architect Velichkin lived on the first floor, and apartment 31 housed the editorial office of the magazine 'Voice of the Past,' where editor S. Melgunov resided. From the early 1900s until 1934, surgeon A. Martynov lived in apartment 18, who headed the surgical clinic of Moscow University and received patients at home. Among the residents were also architect S. Zalesky, lady-in-waiting E. Dolgorukova, inspector I. Razumikhin, choreographer A. Gorsky, artist N. Kazhdan, educator Y. Losev, and others.

Since 1916, the apartment was rented by the founder of the Moscow Chamber Theater A. Tairov with his wife, actress A. Koonen. After the revolution, the house was nationalized, and some families remained in their apartments. Among the new residents was E. Petrovykh, sister of poet M. Petrovykh, who settled in the apartment of architect Zalesky. At that time, owners were allowed to accept tenants at their discretion, and a communal apartment emerged in Zalesky's apartment. Poet O.E. Mandelstam was in love with Maria Petrovykh, and her apartment became a meeting place for the literary bohemia. S.S. Morozov, son of Savva Morozov, also lived in Zalesky's apartment.

In the early 1930s, the house was raised for employees of the State Theater named after V.E. Meyerhold. In 1974, the house was renovated, and new residents moved in, such as test pilot M. Gallai, actress V. Orlova, editor P. Gusev, singer E. Shavrina, actor V. Etush, and judoka S. Novikov.

In the building at the corner of Spiridonovka Street and Granatny Alley lived writer B. Zaytsev, where from 1906, writers and journalists often gathered. Today, the house continues to have residential apartments, while the first floor houses a contemporary art gallery, a dental clinic, a flower shop, a karate club, a wine shop, and other organizations.