The Church of the Life-Giving Trinity in Karacharovo, a regional cultural heritage site, is known as the "Church of the Sign" and dates back to 1784. It is located on land developed since the 12th century, near an ancient road. In the 12th century, Moscow defended the approaches to the Vladimir-Suzdal principality, and the route from Veliky Novgorod to the Oka in the Ryazan principality passed through the modern Nizhny Novgorod region, transporting passengers, goods, and mail.

The first mention of a settlement at the site of Karacharovo dates back to 1516, and in 1571 it was recorded as the estate of the Spaso-Andronikov Monastery. After the Time of Troubles, Karacharovo, referred to as a wasteland, was transferred to the royal steward Vasily Ivanovich Streshnev. He restored the village, built a boyar's courtyard and a wooden church of the Three Holy Hierarchs, and founded a new settlement with 42 peasant households and a church dedicated to the icon of the Most Holy Theotokos.

In 1646 and then in 1661, the village and the settlement were returned to the Andronikov Monastery. Later, a monastery courtyard with gardens appeared on the site of the village, and the settlement grew into a new village of Karacharovo. In 1764, the village was transferred to state administration, and in 1774, a stone church was built on the site of the wooden one, consecrating the main altar in honor of the Holy Life-Giving Trinity. The architectural appearance of the church was formed until 1905.

From 1773 to 1776, a stone church in honor of the Life-Giving Trinity was built. Construction continued thanks to the efforts of the parishioners, and from 1782 to 1836, chapels and a refectory were erected. In 1833-1834, a bell tower was built, and in 1893, the church was expanded.

In 1904-1905, the church was reconstructed after a hurricane. In the late 1930s, it was closed, housing a factory workshop and a sculpture studio, the church's dome was demolished, and the bell tower was rebuilt. In 1992, the church was returned to the faithful in a dilapidated state. In 1993, it was reopened and consecrated after restoration, recreating its original appearance.