By the decree of Tsar Alexei Mikhailovich, a women's almshouse for 30 poor women was built in Skopino in 1668, who were paid 2 rubles annually from customs and tavern revenues, as well as receiving 2 quarters of rye and oats from the tithe bread.

In 1690, the elderly residents of the almshouse, including Akilina and her sisters, appealed to Tsars Ivan and Peter Alexeyevich with a complaint that their homes were located in the trading square, where it was impossible to live due to shameless people. They proposed to use the vacant stable yard by the Kazan Church, which had been empty since 1683, for a monastery. In 1691, the tsars instructed the chamberlain and voivode Abraham Pasynkov to relocate the elderly women to this site and build a church there.

After the monastery was established, the nuns of the Ascension Monastery received monetary and bread allowances from the Skopino Chancellery. In 1693, the monastery was rebuilt, and on August 9, 1694, Metropolitan Avraamy blessed the elderly woman Maria for the position of abbess. In 1744, abbess Alexandra was issued a book to complete the construction of the new church.

By the decree of 1722, there were to be 30 nuns in the monastery, as well as a priest, deacon, subdeacon, and sexton. The monastery had no other sources of income besides the allowances, and in 1764 it was abolished, and the church became a parish church.

In the former monastery's Ascension Church, an altar in honor of the Smolensk Icon of the Mother of God was consecrated on November 13, 1784. In 1809, the church was rebuilt. In 1857, the altar was renamed in honor of the Mother of God, Joy of All Who Sorrow, but in 1878 it was dismantled, and a new one with two altars was built in its place.

The church had 900 rubles, of which 600 belonged to the parish. The parish recorded 357 men and 398 women. According to the 1873 staff, the parish had a priest and a psalmist.

On July 16, 1951, the regional executive committee decided to demolish the building of the Ascension of the Lord Church in Skopino. After the church was closed in the 1930s, a collective farm market was established on its territory, which still operates today. In 2009, the reconstruction of the church building began.