The village of Efimyevo was transferred in 1564 by the boyar Shein to the ownership of the Rostov Epiphany Monastery and remained its property until 1764. According to records from 1678, there was a wooden church of St. Nicholas the Wonderworker here in the 17th century, where a priest named Semyon served. The village had 14 peasant households and 13 landless households, with a total population of 116 men.

In 1693, a new church was built in the name of the Life-Giving Trinity, likely on the site of the one that had burned down. In 1779, it was replaced by another church. Shortly before that, in 1776, another church dedicated to St. Nicholas was erected.

However, these churches stood only until 1818, when a stone church of the Holy Trinity with a chapel of St. Nicholas the Wonderworker was built in their place, which has survived to this day.

In 1892, a district public school opened at the church, and by 1893, it had 38 students.

During the Soviet period, the church was closed and suffered destruction: the bell tower and dome were destroyed. Currently, the church has been returned to the faithful, and renovation work is underway.