From Varvarka towards Ilinka leads Ipatievsky Lane, which is open only on weekdays. It is possible to reach the Church of the Life-Giving Trinity in Nikitniki along this lane. This place remained undeveloped for a long time and was called "Glinishchi" due to the clayey soil.

The name "Nikitniki" has a dual origin: it may be related both to the ancient church and to the surname of the estate owner. However, the church burned down during one of the Moscow fires, and the goods stored in the estate also suffered. Between 1628 and 1634, Grigory Nikitnikov built a new stone temple at his own expense, which has survived to this day. Nikitnikov pursued practical goals: the Church of the Life-Giving Trinity had hiding places for storing valuables, and in the basement, a storage room. The temple, executed in the style of Russian ornamentation, turned out to be ornate, and its features became a model for many other Moscow churches. For example, the tented entrance to the church first appeared here. The frescoes in the Church of the Trinity in Nikitniki, which have been well preserved to this day, were created by Simon Ushakov.

The Georgian icon was considered miraculous, attributed with delivering Moscow from the plague in 1654. This was a copy of the icon that the Persian Shah Abbas, who conquered Georgia in 1622, sold to Russian merchants. The original icon is kept in the Krasnogorsk Monastery on the Pinega River. During the Soviet years, the Church of the Life-Giving Trinity in Nikitniki was transferred to the State Historical Museum. The church is currently active.