The history of Derhachi begins with the first settlements in Sloboda, and this place is mentioned in a charter from 1682. In the 18th-19th centuries, there were two churches here: St. Nicholas and the Nativity of the Virgin.

The Church of St. Nicholas was founded in 1660. In the late 19th century, Filaret Gumilevsky wrote that a silver altar cross, donated by Osip Mironovich in 1717, is kept in the current Church of St. Nicholas. A wooden church was built in 1780 and recently adorned: a new iconostasis, a canopy over the altar, and a heavenly place cost the parishioners 2800 rubles in silver. Noblewomen Elizaveta Krasnokutskaya, Radchenkova, and Ekaterina Trukhmanova donated three silver vestments for local icons, each worth three hundred rubles.

It is known about the Church of the Nativity of the Blessed Virgin Mary that on June 5, 1691, the Belgorod voivode Boris Sheremetev wrote to the Kharkiv voivode Semyon Durnov about the request of priest Yakov from Derhachi for a plot of land to build a church. Yakov built the church in the name of the Nativity of the Blessed Virgin Mary but did not receive a salary. In 1686, instead of a salary, he was allocated 50 quarters of vacant land. Yakov Turansky, the builder of the church, had previously served in the Nicholas church.

The Church of the Nativity of the Blessed Virgin Mary was consecrated in 1685. In April 1765, Yakov Turansky's great-grandson, priest Timofey Turansky, received a blessing to build a new wooden church. In 1838, a new stone church was consecrated, built by priests Fyodor Turansky, Fyodor Palevsky, landowners Alexander Astashevsky, Semyon Kvitka, and parishioners. The church was wealthy, possessing ancient biblical books from the 17th century, icons, crosses, and utensils from the 18th century, donated by local landowners.

After the 1917 revolution, the church was closed. During the Great Patriotic War, services resumed, but in the 1950s, the church was closed again. At the request of the residents, the church was reopened in the 1960s. Today, restoration work is completed, and services continue.