The Biysk Bishop's House has been the central structure of the bishop's courtyard for over a hundred years. From 1883 to 1919, it played a key role in the spiritual life of a vast region encompassing northeastern Kazakhstan, Khakassia, the Altai Republic, and part of the Altai Territory. The Altai Spiritual Mission operated here, supporting hundreds of churches, parish schools, educational institutions, monasteries, and shelters.

The original two-story bishop's house with a mezzanine was built between 1880 and 1882 with funds from Biysk merchants and other benefactors. It was consecrated by the first Biysk bishop, Vladimir Petrov. However, on the night of May 22, 1886, the building burned down, destroying all property, the library, and archives. Bishop Makary managed to save the altar cross, Antimension, and the Gospel.

A new house was built from 1886 to 1888 with donations from the residents of Biysk and other cities. The project was developed by architect Sergey Vladislavlev. In 1888, the new brick building was consecrated, and on September 21 of the same year, Bishop Makary Nevsky consecrated the church in honor of St. Dimitry of Rostov, located on the third floor. The church housed an icon of St. Great Martyr Panteleimon with a relic of his remains.

In the early 20th century, a book warehouse operated at the house, selling icons, liturgical books, and textbooks. According to data from 1910, the complex included 11 buildings, including the Kazan Church and several residential and utility buildings. The territory was enclosed by a fence with stone gates.

In 1920, the building was nationalized and used for various needs, including housing schools and an evacuation hospital. In 2002, the buildings were returned to the Russian Orthodox Church, and restoration began. In 2003, the building was officially transferred to the Barnaul Diocese. Since 2009, the Bishop's House has housed exhibitions of the museum of the history of the Altai Spiritual Mission, and a domestic church has been recreated in the mezzanine.