This bright mansion with medallions invariably attracts the attention of passersby in Kaloshin Lane. Wooden, one-story with a mezzanine and white stone basement, the house was built in 1852 by architect Mikhail Lopyrevsky for his own residence.

From 1848 to 1883, the plot at the corner of Arbat and Kaloshin Lane belonged to architect Mikhail Osipovich Lopyrevsky. According to legend, he was an illegitimate son of one of the Golitsyn princes and was raised in the family of titular advisor Lopyrev. Mikhail Osipovich participated in the construction of the Armory and the Horse Guards' Corps in the Kremlin, was a member of the committee for the construction of the Cathedral of Christ the Savior, and taught at the Agricultural School. In his possession, he first built his own house, and then in 1869, according to the project of architect Ilya Yakovlevich Bykovtsev, began to erect two stone two-story residential buildings along the red line of Arbat and Kaloshin Lane, one of which later received a third floor. In 1876, Lopyrevsky demolished the one-story wooden house between the buildings and built a three-story stone one in its place, combining it with the other two into a single income-generating structure.

The layout of the architect's own house was carefully thought out: from the outside, the mansion looked small and modest, while inside it was spacious and luxurious. This is confirmed by his statement that "a building is composed not by its facade, but by its plan, from which the facade and section depend... and each of these items depends on one another."

After Lopyrevsky's death, the house housed a maternity shelter, and then various medical institutions. Since the 1970s, the building was rented by "Zarubezhgeologiya." Only in 1993 did Lopyrevsky's mansion receive the status of an architectural monument, and in 1997, its complete restoration began. During the restoration, wooden panels with unique tempera paintings in the style of arabesques on the ceiling, beams, doors, and door frames were unexpectedly discovered under the late cladding. A total of 1230 fragments and a door with painted canvases were cleared. Wallpapers, likely created based on sketches by Lopyrevsky himself, were also found, representing significant artistic value. The results of the restoration can be seen during cultural heritage days.