Zamoskvorechye is traditionally associated with merchants and craftsmen, but this opinion is not entirely accurate, as noble estates were also located here. In one of the alleys connecting Bolshaya Polyanka and Yakimanka streets, there were the holdings of P.G. Vyazemsky, a representative of the famous Vyazemsky family, which traces its lineage back to the legendary Rurik. The Vyazemsky estate in Zamoskvorechye was located on Spasonalivkovsky Alley, which was called Tarakanov in the 18th century and Bolshoy Spassky in the 19th century. The name 1st Spasonalivkovsky only appeared in the last century. According to one version, it is related to the settlement of Nalivka, which was near the "flooded (nalivnoy) meadow."

The alley is located in the center of modern Moscow between Yakimanka and Bolshaya Polyanka streets, not far from the Oktyabrskaya metro station and the Garden Ring. House No. 4, located closer to Bolshaya Polyanka, was also part of the Vyazemsky estate. The estate was divided into plots and sold to various owners in the 19th century. In the 1870s, building 4 on 1st Spasonalivkovsky Alley acquired its modern appearance: a two-story stone house was rebuilt, decorative wreaths appeared under the cornice, and cherubs with garlands were added to the pediment under the roof. The windows of the first floor are adorned with original-shaped keystones.

In the late 1880s, the Yakimanka part of the 2nd plot, where the modern house 4 is located, belonged to merchant Ivan Guchkov, and later to his daughter Tatyana Guchkova. A plan of the plot and a description of the buildings and the people living in them have been preserved in the Moscow archive. It was a medium-sized merchant estate with six buildings and a garden. The main two-story stone house with a basement, which housed a laundry and a pantry, was home to the owners' family. The plot also contained two wooden residential buildings rented out. One single-story house had a mezzanine, while the two-story one had a balcony. Additionally, there was a stable for three stalls and a janitor's house, next to which was an outbuilding.

During the Soviet era, apartments in residential buildings turned into communal apartments. The wooden structures did not survive until the 1960s, and the main house became so dilapidated that it was planned for demolition. However, many Honored and People's Artists of the USSR advocated for its preservation. After the inclusion of the Vyazemsky estate house in the list of architectural monuments, restoration began, which was completed in 1984.

In 1996, the building housed the "Union of Moscow Sculptors," which created the "Moscow House of Sculptor" based on the estate. Since then, monthly exhibitions of sculpture, painting, and graphics, as well as classical music concerts and literary evenings, have been held here.

In 2007, after the liquidation of the House of Sculptor, the estate became home to the Intergovernmental Fund for Humanitarian Cooperation of the CIS member states, which remains here to this day.