The Alexander-Mariinsky School for the Blind was an educational institution for children with visual impairments in the Russian Empire. It opened in 1880 as a private initiative and was initially located in an apartment on Tavricheskaya Street, rented with funds from K. K. Grot. Two blind boys began their education there. In 1881, the school became part of the Empress Maria Alexandrovna's Guardianship for the Blind, which was also established at Grot's initiative.

In 1883, the Guardianship began working on the construction of a separate building for the school. To this end, F. Bütner, the director of the Dresden Institute for the Blind, was invited to Russia. The Guardianship allocated 250,000 rubles from its reserve capital, and the city administration provided a plot of land from the former Karpovsky Cemetery on Aptekarsky Island for a small fee. Architect A. O. Tomishko was appointed. Construction began on June 2, 1888, and by the fall of 1889, the building was nearly complete. On May 29, 1890, Bishop Anthony of Vyborg consecrated the building along with the church of Equal-to-the-Apostles Mary Magdalene on the third floor. The school was a three-story building with two outbuildings, including living quarters, classrooms, apartments for staff, a bathhouse, a laundry, and other amenities. Thanks to the efforts of N. N. Hartman, a garden was established at the school, to which V. A. Ratkov-Rozhnov donated 1,000 rubles.

In 1888, Alexander III allocated a charitable capital of 1,050,000 rubles to the school, bequeathed by Alexander II after the death of his wife. From that moment, the school existed mainly on the interest from this capital, which amounted to about 50,000 rubles per year, and it was renamed the Alexander-Mariinsky School. Private donations were also accepted for the establishment of named scholarships, which required a contribution of 4,000 rubles.

In 1885, G. P. Nedler, who had interned at the Dresden Institute for the Blind, became the director of the school. The school accepted blind children of all classes aged 7 to 11, both free of charge and for a fee. The paid boarding cost 300 rubles per year, while day students paid 60 rubles. The school consisted of a preparatory department with two classes and a school with three classes. After completing the school classes, students entered the craft department, where they learned basket weaving and brush making. Girls studied handicrafts, while boys were taught singing, music, and piano tuning. There were choral classes, and general education was provided in the style of urban two-class schools. In the 1900s, pedagogical courses operated at the school to train teachers for regional schools for the blind. Graduates of the craft department finished at the age of 19-20, and if necessary, they received support from a special fund.

By 1885, 55 children were studying at the school, and the first graduation took place in 1890. By 1892, the number of students reached 100, and by 1911, 120. In 1889, a monument to K. K. Grot, created by M. M. Antokolsky and his students, was installed in front of the school building. In 1904, a shelter for blind women with 120 places opened on the school grounds in memory of Elizaveta Kudyura.

The school continued its work after the revolution. In 1963, it moved to a new building at 44 Shaumyan Avenue, and the monument to K. K. Grot was relocated to a park in front of the new building. The old school building was transferred to the Leningrad Electrotechnical Institute named after V. V. Bonch-Bruevich.