In 1810, Major General A.A. Tuchkov built an estate complex at the corner of Prechistenka and Mansurovsky Lane, consisting of three buildings: the main house, erected on the site of old chambers, a wing, and service buildings in the courtyard. The fire of 1812 did not damage the main house, and around 1817, Count S.P. Potemkin acquired this property. Subsequently, the owners changed multiple times, and in 1871-1872, at the request of the new owner A.P. Martynova, architect P.S. Campioni reconstructed the main house, adding an extension from the lane side and decorating the facade in an eclectic style.

In 1889, the estate was purchased by the famous industrialist and philanthropist Ivan Abramovich Morozov. Under him, the service building (now the building of the Institute of History of Arts) was reconstructed, and a stone fence was erected, separating the estate from the Alexander-Mariinsky Institute for Noble Maidens. In 1905, architect L.N. Kekushev reconstructed the main house to house Morozov's collection, consisting of Western European and Russian paintings from the late 19th and early 20th centuries. In the mansion, a so-called fireproof room was created with thick stone walls, a concrete vaulted ceiling, two small windows, and a double-leaf door, where the entire collection could be hidden. In the 1920s, the L.N. Tolstoy Museum used this room to store the writer's manuscripts. The architect also removed the abundant stucco in the enfilade rooms facing Prechistenka, leaving the dining room in Gothic style. Decorative panels and sculptures for the concert hall and grand staircase were created by French artists M. Deni, A. Maillol, and P. Bonnard.

Morozov's collection was almost inaccessible for viewing, and he planned to transfer it to Moscow, but the revolution changed his plans. The gallery was nationalized and became the basis for the Museum of New Western Art, while the former owner became the deputy director of this museum. At the end of 1918, Morozov emigrated.

The Museum of New Western Art was often visited by Osip Mandelstam, who could see works by Impressionists, Van Gogh, Cézanne, and other artists. These visits inspired him to create the poem "Impressionism" and the chapter "The French" from "Journey to Armenia."

In 1929, a partial reconstruction of the main house was carried out according to the project of architect S. Kalugin, during which a new exhibition hall was created. Since 1947, the estate has housed the Presidium of the Academy of Arts of the USSR, now the Russian Academy of Arts, along with the Research Institute of Theory and History of Fine Arts.

The house is an object of cultural heritage of federal significance.