Before the 1917 revolution, this estate belonged to the family of well-known and wealthy industrialists, the von Vogaus. Since the 1920s, it has housed the L.Ya. Karpov Scientific Research Institute of Physical Chemistry.

In 1878, Hugo von Vogau, head of the trading company "Vogau & Co," acquired a plot at the corner of Vorontsovo Pole Street and Krivogruzinsky Lane (now Obukh Lane). Soon, he added the neighboring plot to his property. The old buildings were demolished, and in 1882, a new two-story house was built for the von Vogau family, designed by architect Viktor Kossov. The initial plan was to create an estate in an eclectic style with elements of German Baroque, featuring a high roof and richly decorated facade. However, a more concise neoclassical design was realized. The facade of the house, set back from Vorontsovo Pole Street, was smoothly plastered and adorned with pilasters and strips, topped with a cornice and stone parapet. In contrast to the modest facade, the interiors were luxuriously decorated, also designed by Kossov.

The estate, located on the slope of the high bank of the Yauza River, featured a landscaped park. The main avenue, lined with linden trees, led from the gates on Vorontsovo Pole Street downwards, while a side avenue ran from the gates in the lane. In the center of the park, oaks grew, and at the bottom, there was a greenhouse.

Hugo von Vogau came from a declining German noble family. His father, Maximilian von Vogau, arrived in Russia in 1827 and within a decade became the owner of his own firm, founded with his brothers in 1840. The Vogaus started with trading colonial goods and later invested in other industries and banking. By the end of the 19th century, their enterprise had become a diversified conglomerate with immense capital, and Hugo von Vogau and his relatives were among the wealthiest merchants and industrialists in the Russian Empire. Hugo was awarded the title of Commercial Advisor and the Orders of St. Stanislaus and St. Anna, was a member of the Moscow Architectural Society, and a founder of the Committee for the Arrangement of the Museum of Fine Arts in Moscow, actively engaging in charity work.

Russia's entry into the war with Germany in 1914 marked a turning point for the von Vogau family. The war sparked anti-German sentiments, leading to riots. In May 1915, many German shops and homes in Moscow were looted within three days. Hugo von Vogau's mansion on Vorontsovo Pole was burned down, leaving only the walls. After this, the family decided to sell their businesses and leave Russia.

The mansion on Vorontsovo Pole remained semi-ruined until the early 1920s, when the estate was nationalized by the Bolsheviks and transferred to the Physical Chemistry Institute. In 1922, the house was restored and expanded to three floors according to the design of architect S.E. Chernyshev. It became the main laboratory building of the institute, with apartments for staff on the upper floor. In 1927, a semi-factory experimental station building was constructed deeper within the estate, designed by Boris Iofan in the constructivist style. Gradually, the territory was developed with new buildings. In the late 1940s, a new laboratory building with a tower was constructed in the lower part. Despite the new construction, the central part of the park has been preserved, although it has taken on a neglected appearance.

Unfortunately, the institute's territory has remained closed to visitors since Soviet times.