The Ustyug Spassky Convent, also known as the Ustyug Sretensky or Transfiguration Convent, was located in Veliky Ustyug and was founded in 1422 at the parish church.

By 1623, there were wooden churches on the monastery grounds: the cold Church of the Transfiguration of the Lord and the warm Church of the Meeting of the Lord. The monastery was managed by Abbess Martha, and 54 elders lived in 12 cells, relying on alms.

After the fire in 1679, a wooden warm church and a stone cold church were built. By 1693, the number of cells increased to 29.

The construction of the first stone church began in 1689, and it was consecrated in 1697 in honor of the Transfiguration of the Lord.

In 1715, the warm wooden church burned down, and a warm chapel was arranged in the refectory of the Transfiguration Church, consecrated in 1718 in honor of the icon of the Mother of God "Kazan."

The construction of the warm stone church began in 1725, and it was consecrated in 1740 in honor of the Meeting of the Lord.

In 1764, the Spaso-Transfiguration Monastery was abolished, and the nuns were transferred to the Ustyug John the Baptist Monastery, which had previously been a men's monastery. The churches of the former monastery became parish churches.

In the 18th-19th centuries, the Spaso-Transfiguration parish church in Ustyug continued to operate. In 1794, the Kazan chapel was consecrated in the warm Sretensky church, and in 1797, the chapel of Saints Joachim and Anna was consecrated in the cold Transfiguration church. The bell tower was located in the northwest corner of the Transfiguration church. In 1855, a stone fence was built instead of the wooden one with funds from merchant Ilya Yakovlevich Gribanov. In 1788, the parish had 536 souls, and in 1868, 265.

In the 20th century, the Spaso-Transfiguration parish church continued to function. In 1915, there were 464 people in the parish. Archpriest Ilarion Yakovlevich Chernyaev, a graduate of the Vologda Theological Seminary, served there.

The last service in the Spaso-Transfiguration church took place in 1928, after which the buildings were transferred to the Northern Dvina Provincial Archive.

In 1931, Chernyaev Ilarion Yakovlevich was arrested and exiled to the Northern Territory for 3 years, and in 1932 he was exiled to Western Siberia. The further fate of the priest is unknown.

Currently, the buildings of the churches house the Veliky Ustyug Central Archive.