The Transfiguration Church began construction around 1684, simultaneously with the Introduction Church for the women's monastery. The architect Login Korsakov led the construction, backed by the Myasnikov brothers from Solikamsk, who highly valued his work.

Initially, the construction progressed quickly, and within three years, the walls and vaults were erected. However, due to an error, the vaults collapsed, and the pace of work slowed down. Nikita Tretyakov, a local official, was appointed to oversee the further construction, also responsible for fundraising for the monastery at the order of the voivode Naryshkin.

On September 6, 1692, the Transfiguration Church was consecrated. It was located on the eastern outskirts of Solikamsk, sending off and welcoming travelers to Siberia with its bell ringing. Evdokia Shchepotkina, the organizer of the monastery, often prayed in this church, living out her days under the name Sister Melania. She died in 1723 and was buried behind the altar of the temple. After the monastery was closed, the Transfiguration Church, like the Introduction Church, became a parish church.

In the early 1930s, the church was closed, the iconostasis was dismantled, some icons were hidden by parishioners, while others were destroyed. During the war, the building was used for military needs: first, it served as a garage, for which a gate was broken in the wall, and then the church was handed over to the Kamyshin Military Air-sled School, with new gates made for the air-sleds. After the war, various organizations occupied the building.

In the 1950s, scientific restoration was carried out, lost details were restored, and breaches in the walls were sealed. Since 1991, the church has been active again, one of the first in Solikamsk.