The Sokolnicheskaya Infectious Hospital was built between 1899 and 1904 at the request of the Moscow authorities, with funding from the city budget. It was the first specialized infectious hospital in Moscow, allocated an entire block between Matrosskaya Tishina Street and 4th and 5th Sokolnicheskaya Streets. The main building of the hospital faced Stromynskaya Square, which was later developed, and now it overlooks 2nd Boyevskaya Street.

The hospital was intended for the treatment of infectious patients, so the buildings, mostly two stories high, were located at a certain distance from each other to avoid the transmission of infections between patients. Trees were planted between the buildings. The architectural appearance of the hospital is in an eclectic style with elements of neo-Russian architecture, designed by architect Alexander Ivanovich Roop. The hospital complex has preserved its original form, with no changes in layout or reconstructions. During the Soviet era, only one new building, Block 18, was added. The original fence with gates has also been preserved.

In 1904, a church was built on the hospital grounds in honor of the icon of the Mother of God "Utoliy Moya Pechali," facing Matrosskaya Tishina Street. During the Soviet years, the church was closed and stripped of its domes, and its building was used for the needs of the hospital. Currently, the church building has not been returned to the faithful and is used as the hospital's pathology department.

Initially, the Sokolnicheskaya Hospital treated various diseases such as scarlet fever, typhus, smallpox, and malaria. During the Soviet period, the Institute of Infectious Diseases was established based on the hospital, which was abolished after the war, and the hospital was repurposed for tuberculosis treatment. It now functions as Tuberculosis Clinical Hospital No. 7.