In our city, the second oldest Orthodox church after the Holy Nicholas Cossack Cathedral has been preserved, built during the pre-revolutionary times. The initiator of its construction in 1858 was the Governor-General of Western Siberia and the Military Ataman of the Siberian Cossack Army, Gustav Christianovich Gasford. Funds for the construction came from military personnel, officials, Cossacks, and residents not only of Omsk but also of other cities such as Kainsk, Tomsk, Mariinsk, and Tyumen.

The location for the church was chosen with consideration for the convenience of residents from two suburbs of the city. Gasford proposed to build the church in the Kadyshyevsky suburb. In 1862, he left for the capital but continued to support the project by sending donations. The new Governor-General A. O. Dyugamel chose a site on the border of the Kadyshyevsky and Butyrsky suburbs. The construction was supervised by Omsk architect E. I. Ezet, and in 1870, architects F. F. Wagner and V. K. Geide inspected the building.

Merchant of the first guild Grigory Petrovich Andreev, an Orthodox Christian of Kazakh origin, became the benefactor and builder of the church. By 1867, the building was erected, but due to Andreev's death, its completion was delayed for three years. The church was consecrated on September 22, 1870, by Saint Stephen of Omsk. The second altar appeared on February 12, 1896, in honor of the icon of the Mother of God "Heal My Sorrows."

In the early 1900s, the walls of the church were painted in the style of the Cathedral of Saint Vladimir in Kyiv. Before the revolution, the icon of the Abalak Mother of God was especially venerated. Since 1891, a school for girls operated at the church, educating 80 students. In 1901, public readings began, and the church became a center of parish life.

In 1913, the parish recorded 903 baptisms, 98 marriages, and 572 funerals. The number of parishioners reached 6,507. Despite the Civil War, a garden was planted near the church in 1919.

With the arrival of Soviet power, difficult times began. In 1924, parishioners decided to join the Tikhon group, and in 1926, the community was registered. In 1930, 473 books were confiscated from the church, and in 1933, clergy were accused of anti-Soviet activities. In 1936, a decision was made to demolish the church, but protests from parishioners halted this. In 1937, the building was closed and turned into a dormitory.

In 1943, the community was re-registered. Since 1946, the church became the cathedral of the Omsk-Tara diocese. In 1951, a third altar was consecrated in honor of the Prophet Elijah. In the late 1980s, the church underwent changes: the iconostasis was reconstructed, and the painting was updated. In 1988 and 1990, two chapels were added to the building, but they were not consecrated.

In 1980, the church was recognized as a monument of history and culture. In 2011, the number of parishioners was about 300. In 2009, new domes were installed with donations, and the refectory organizes charitable lunches. The Sunday school at the church has been operating for 15 years.